66 Results for "

DNA adduct

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "DNA adduct" in MCE Product Catalog:

19
Azoxymethane
Azoxymethane
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19 Publications Verification
Cat. No.: HY-111375
CAS No.: 25843-45-2
Synonyms: AOM
Target:  

DNA Alkylator/Crosslinker

Research Areas:  

Cancer

Azoxymethane (AOM) is a colon carcinogen which leads to the formation of DNA adducts. Azomethane is a procarcinogen that requires metabolic activation via cytochrome P450 (P450) enzymes (primarily CYP2E1) .
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2
2-Hydroxyestradiol
2-Hydroxyestradiol
0 Images
2 Cited Publications
Cat. No.: HY-124489
CAS No.: 362-05-0
Purity:  ≥97.0%
Category:  

Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
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2
TAK-418
TAK-418
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2 Cited Publications
Cat. No.: HY-138830
CAS No.: 1818252-53-7
Purity:  99.81%
Target:  

Histone Demethylase

Research Areas:  

Neurological Disease

TAK-418 is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .
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2
2,6-Dithiopurine
2,6-Dithiopurine
0 Images
2 Cited Publications
Cat. No.: HY-W016286
CAS No.: 5437-25-2
Synonyms: 2,6-Dimercaptopurine
Target:  

Biochemical Assay Reagents

Research Areas:  

Cancer

2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .
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1
Aristolochic acid B
Aristolochic acid B
0 Images
1 Cited Publications
Cat. No.: HY-N0511
CAS No.: 475-80-9
Synonyms: Aristolochic acid II
Category:  

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:  

DNA Alkylator/Crosslinker

Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510) .
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1
Isopimpinellin
Isopimpinellin
0 Images
1 Cited Publications
Cat. No.: HY-N0769
CAS No.: 482-27-9
Category:  

Coumarins Plants Infection Microorganisms 500 - Internal Server Error | MedChemExpress

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