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47 Results for "

DNA binding site

" in MedChemExpress (MCE) Product Catalog:

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Diminazene aceturate

15 Publications Verification

Cat. No.: HY-12404

CAS No.: 908-54-3

Purity: 99.16%

Synonyms: Diminazene diaceturate

Target:

Parasite Angiotensin-converting Enzyme (ACE)

Research Areas:

Infection Inflammation/Immunology

Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .

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PD 151746

7 Cited Publications

Cat. No.: HY-19749

CAS No.: 181765-30-0

Target:

Proteasome Interleukin Related

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

PD 151746 is a selective calpain-1 inhibitor with an IC₅₀ of 260 nM. PD 151746 binds μ-calpain Ca ²⁺-binding sites, and shows selectivity over cathepsin B, papain, trypsin, thermolysin, and basal calcineurin. PD 151746 reduces Oxidized low-density lipoprotein (oxLDL)-induced cytotoxicity, apoptotic DNA fragmentation, and blocks IL-1α maturation. PD 151746 can be used for the research of atherosclerosis and psoriasis .

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