31 Results for "

DNA-cross-linking

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "DNA-cross-linking" in MCE Product Catalog:

25
6-Aminonicotinamide
6-Aminonicotinamide
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25 Publications Verification
Cat. No.: HY-W010342
CAS No.: 329-89-5
Target:  

NADPH Oxidase

Research Areas:  

Cancer

6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP +-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .
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7
Bendamustine hydrochloride
Bendamustine hydrochloride
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7 Cited Publications
Cat. No.: HY-B0077
CAS No.: 3543-75-7
Synonyms: SDX-105
Target:  

DNA Alkylator/Crosslinker Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
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7
Bendamustine
Bendamustine
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7 Cited Publications
Cat. No.: HY-13567
CAS No.: 16506-27-7
Purity:  ≥98.0%
Synonyms: SDX-105 free base
Target:  

DNA Alkylator/Crosslinker Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
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3
SJG-136
SJG-136
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3 Cited Publications
Cat. No.: HY-14573
CAS No.: 232931-57-6
Purity:  99.47%
Synonyms: NSC-694501
Target:  

DNA Alkylator/Crosslinker ADC Payloads

Research Areas:  

Cancer

SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.
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1
UBE2T/FANCL-IN-1
UBE2T/FANCL-IN-1
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1 Cited Publications
Cat. No.: HY-126539
CAS No.: 1359415-02-3
Purity:  99.83%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .
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1
PR-104A
PR-104A
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1 Cited Publications
Cat. No.: HY-14572
CAS No.: 680199-06-8
Synonyms: SN 27858
Target:  

DNA Alkylator/Crosslinker Drug Metabolite

Research Areas:  

Cancer

PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .
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PR-104
PR-104
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Cat. No.: HY-16405
CAS No.: 851627-62-8
Target:  

DNA Alkylator/Crosslinker

Research Areas:  

Cancer

PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .
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trans-Platinum(II)diammine dichloride
trans-Platinum(II)diammine dichloride
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Cat. No.: HY-W075885
CAS No.: 14913-33-8
Synonyms: trans-platinumdiamminedichloride
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .
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Trimethylbenzoquinone
Trimethylbenzoquinone
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Cat. No.: HY-W100491
CAS No.: 935-92-2
Target:  

Drug Derivative

Research Areas:  

Cancer

Trimethylbenzoquinone (Compound 5) is a methylated benzoquinone. Trimethylbenzoquinone exhibits moderate cytotoxicity against K562 cells, with its IC50 being 0.75 μM. Trimethylbenzoquinone is completely unable to cause inter-strand DNA cross-linking and cannot alkylate DNA guanines. Trimethylbenzoquinone can be used to study the relationship between the nitrogen heterocyclic group and DNA cross-linking .
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SJG-136 intermediate-1
SJG-136 intermediate-1
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Cat. No.: HY-402091
CAS No.: 232931-64-5
Target:  

ADC Payloads

Research Areas:  

Others

SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA .
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1-Chloromethylpyrene
1-Chloromethylpyrene
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Cat. No.: HY-W111005
CAS No.: 1086-00-6
Target:  

DNA Alkylator/Crosslinker

Research Areas:  

Cancer

1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells .
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Aniline mustard
Aniline mustard
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Cat. No.: HY-121713
CAS No.: 553-27-5
Purity:  99.36%
Synonyms: N,N-Bis(2-chloroethyl)aniline
Target:  

DNA Alkylator/Crosslinker

Research Areas:  

Cancer

Aniline mustard (N,N-Bis(2-chloroethyl)aniline) is a DNA cross-linking agent. Aniline mustard can be released from quinone-based prodrugs after NQO1-mediated reduction. Aniline mustard exhibits antitumor activity in mice. Aniline mustard can be used for research on tumors .
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PBD dimer-4
PBD dimer-4
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Cat. No.: HY-175004
CAS No.: 1821339-88-1
Target:  

ADC Payloads DNA Alkylator/Crosslinker

Research Areas:  

Cancer

PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types .
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LS-BF1
LS-BF1
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Cat. No.: HY-P3350
CAS No.: 2892148-58-0
Target:  

Bacterial

Research Areas:  

Infection

LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
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Echihumiline
Echihumiline
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Cat. No.: HY-N16478
CAS No.: 174285-73-5
Category:  

Pyrrolizidine Alkaloids Alkaloids Boraginaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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