41 Results for "

DU145

" in MedChemExpress (MCE) Product Catalog:
Products (41)

41 Results for "DU145" in MCE Product Catalog:

3
AS 1411
AS 1411
0 Images
3 Cited Publications
Cat. No.: HY-147081
CAS No.: 301636-59-9
Purity:  99.52%
Synonyms: AGRO-100
Target:  

Histone Methyltransferase Bcl-2 Family

Research Areas:  

Cancer

AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .
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3
AS 1411 sodium
AS 1411 sodium
0 Images
3 Cited Publications
Cat. No.: HY-147081A
Synonyms: AGRO-100 sodium
Target:  

Histone Methyltransferase Bcl-2 Family

Research Areas:  

Cancer

AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity
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2
EF24
EF24
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2 Cited Publications
Cat. No.: HY-119272
CAS No.: 342808-40-6
Purity:  99.34%
Target:  

ERK Caspase NF-κB Apoptosis p38 MAPK Reactive Oxygen Species (ROS)

Research Areas:  

Inflammation/Immunology Cancer

EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .
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1
ABT-100
ABT-100
0 Images
1 Cited Publications
Cat. No.: HY-119257
CAS No.: 450839-40-4
Purity:  98.18%
Target:  

Farnesyl Transferase Apoptosis

Research Areas:  

Cancer

ABT-100, a chemical probe, is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity .
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Epifriedelanol
Epifriedelanol
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Cat. No.: HY-N1931
CAS No.: 16844-71-6
Category:  

Triterpenes Anti-aging Terpenoids Plants 500 - Internal Server Error | MedChemExpress

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