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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Delpacibart
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Delpacibart" in MCE Product Catalog:
Cat. No.: HY-P990051
CAS No.: 2653183-66-3
Synonyms: AOC-1001 Antibody; AOC-1044 Antibody
Research Areas:
Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
Cat. No.: HY-177564
CAS No.: 2929240-20-8
Synonyms: Del-zota; AOC 1044
Target:
Antibody-Oligonucleotide Conjugates (AOCs) Transferrin Receptor Dystrophin Antibody-Drug Conjugates (ADCs)
Research Areas:
Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1) .
Cat. No.: HY-177971
Research Areas:
Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran (HY-177566), consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker (HY-42360). Delpacibart braxlosiran binds to TfR1. Aberrant expression of the DUX4 protein causes changes in gene expression in muscle cells, which are associated with muscle function loss in facioscapulohumeral muscular dystrophy (FSHD) .
Cat. No.: HY-177972
Research Areas:
Zotadirsen is the core component of the AOC drug Delpacibart zotadirsen (AOC1044) (HY-177564), consisting of a phosphorodiamidate morpholino oligonucleotide (PMO) targeting exon 44 of the dystrophin gene and an SMCC linker (HY-42360). Upon conjugation with the anti-TfR1 antibody Delpacibart (HY-P990051), Zotadirsen exerts splicing regulatory activity and mediates exon skipping. Zotadirsen can be used in studies related to AOC synthesis .
Cat. No.: HY-177971D
Research Areas:
Unconjugated/naked Braxlosiran (without SMCC linker) is the nucleic acid component of Braxlosiran (HY-177971), lacking both the amino group and the SMCC linker. It can be used to synthesize the AOC agent Delpacibart braxlosiran (HY-177566).
Cat. No.: HY-147262
Research Areas:
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .
Cat. No.: HY-147262D
Target:
Antibody-Oligonucleotide Conjugates (AOCs) Small Interfering RNA (siRNA) Myotonin-Protein Kinase (DMPK)
Research Areas:
Unconjugated/naked Etedesiran (without SMCC linker) is a small interfering RNA (siRNA) targeting DMPK, and also represents the unconjugated, non-SMCC linker-bound component of delpacibart etedesiran. Unconjugated/naked Etedesiran (without SMCC linker) corrects pathogenic mRNA aberrant splicing by targeting and degrading mutant DMPK mRNA, thereby releasing sequestered MBNL splicing factors. Unconjugated/naked Etedesiran (without SMCC linker) can be used in studies of myotonic dystrophy type 1 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
