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161 Results for "

Dendritic cells

" in MedChemExpress (MCE) Product Catalog:

Products (161)

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Corticosterone

72 Publications Verification

Cat. No.: HY-B1618

CAS No.: 50-22-6

Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B

Category:

Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Glucocorticoid Receptor Endogenous Metabolite iGluR

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

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Epacadostat

29 Cited Publications

Cat. No.: HY-15689

CAS No.: 1204669-58-8

Purity: 98.47%

Synonyms: INCB 024360

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Inflammation/Immunology Cancer

Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM . Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.

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Jagged-1 (188-204)

19 Cited Publications

Cat. No.: HY-P1846

CAS No.: 219127-21-6

Target:

Notch

Research Areas:

Cancer

Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells .

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Jagged-1 (188-204) TFA

19 Cited Publications

Cat. No.: HY-P1846A

Target:

Notch

Research Areas:

Cancer

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells .

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7α,25-Dihydroxycholesterol

7 Cited Publications

Cat. No.: HY-113962

CAS No.: 64907-22-8

Purity: 99.88%

Synonyms: 7α,25-OHC

Category:

Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids

Target:

EBI2/GPR183 Endogenous Metabolite

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC₅₀=140 pM; K_d=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells .

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