50 Results for "

Derivative 2406

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "Derivative 2406" in MCE Product Catalog:

13
13 Cited Publications
Cat. No.: HY-12068
CAS No.: 1349796-36-6
Purity:  99.46%
Synonyms: XL-147 Derivative 1
Target:  

PI3K

Research Areas:  

Cancer

PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways .
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Cat. No.: HY-172664A
Target:  

Drug Derivative

Research Areas:  

Cancer

Trabectedin derivative 2 TFA (compound PL-12) is a Trabectedin derivative that can be used for the study of cancer .
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Cat. No.: HY-172663A
Research Areas:  

Cancer

Trabectedin derivative 1 TFA is a selective DNA minor groove binder. Trabectedin derivative 1 TFA inhibits DNA transcription and repair to induce tumor cell apoptosis. Trabectedin derivative 1 TFA is promising for research of solid tumors such as soft tissue sarcoma and ovarian cancer .
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Cat. No.: HY-173097
CAS No.: 2086298-33-9
Synonyms: VH032-Boc Derivative 1
(S,R,S)-AHPC-Boc derivative 1 (VH032-Boc derivative 1) is a derivative of (S,R,S)-AHPC-Boc (HY-123109), which is applicable to research related to PROTAC synthesis .
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Cat. No.: HY-176049
CAS No.: 3079237-53-6
Target:  

Drug Derivative

Research Areas:  

Neurological Disease

Dasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma .
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Cat. No.: HY-172664
CAS No.: 3056692-81-7
Target:  

Drug Derivative

Research Areas:  

Cancer

Trabectedin derivative 2 (compound PL-12) is a trabectedin derivative that can be used in research on ovarian cancer, gastric cancer, and breast cancer .
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Cat. No.: HY-163506
CAS No.: 3030492-59-9
Target:  

Apoptosis Ferroptosis

Research Areas:  

Others

Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss .
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Cat. No.: HY-178270
CAS No.: 2305851-17-4
Target:  

ADC Payloads

Research Areas:  

Inflammation/Immunology Cancer

PBD derivative-1 (Compound 7-8) is a derivative of PBD, and PBD is the payload in antibody-drug conjugates (ADCs). PBD derivative-1 can be used for the synthesis of ADCs.
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Cat. No.: HY-P10444
CAS No.: 3033865-40-3
Research Areas:  

Cancer

DOTA Conjugated JM#21 derivative 7 (compound Ligand-7) is a derivative of CXCR4 targeting peptide conjugated with DOTA and can be used to produce radioligands. Radiolabeled DOTA Conjugated JM#21 derivative 7, i.e., 177Lu-DOTA, has excellent CXCR4 tumor targeting. In vitro biodistribution results of 177Lu-DOTA showed very low uptake in all non-targeted organs except kidney . DOTA Conjugated JM#21 derivative 7 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
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Cat. No.: HY-177249
Target:  

Arp2/3 Complex

Research Areas:  

Cardiovascular Disease

Salvianolic acid A derivative-1 (Compound SAA-30) is a orally active derivative of Salvianolic acid A (HY-N0318). Salvianolic acid A derivative-1 binds to transgelin with a KD of 2.39 μM. Salvianolic acid A derivative-1 promotes cell contractions by facilitating the aggregation of actin. Salvianolic acid A derivative-1 can be used for prevention of myocardial ischemia or other diseases associated with IR tissue injuries .
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Cat. No.: HY-P1355A
CAS No.: 286852-20-8
Target:  

Calcineurin Cyclophilin

Research Areas:  

Others

Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cat. No.: HY-N7741
CAS No.: 67667-64-5
Synonyms: Dehydrozaluzanin C-Derivative
Isozaluzanin C (Dehydrozaluzanin c-derivative) is an anti-inflammatory agent that can be isolated from Saussurea lappa and has immunomodulatory effects. Isozaluzanin C improves tissue damage (lung, kidney, and liver) and excessive inflammation in mice induced by LPS (HY-D1056) or CRKP infection. Isozaluzanin C can be used in the study of bacterial infections and sepsi .
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Cat. No.: HY-U00378
CAS No.: 128400-55-5
Target:  

Drug Derivative

Research Areas:  

Cardiovascular Disease

Glycerol derivative 1 is a Glycerol derivative extracted from patent EP 672415 A1, compound (1).
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Cat. No.: HY-101831
CAS No.: 168830-01-1
Heterocyclyl carbamate derivative 1 is a heterocyclyl carbamate derivative that may be used for the research of inflammatory and neurological diseases.
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Cat. No.: HY-177267
CAS No.: 2378619-11-3
Research Areas:  

Cancer

Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research .
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Cat. No.: HY-P1354
CAS No.: 156047-45-9
Target:  

Calcineurin Cyclophilin

Research Areas:  

Others

Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cat. No.: HY-P1355
CAS No.: 1487360-85-9
Target:  

Calcineurin Cyclophilin

Research Areas:  

Inflammation/Immunology

Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cat. No.: HY-100177
CAS No.: 852055-88-0
Research Areas:  

Others

L-Threonine derivative-1 is a acetylsalicylic-L-threonine ester extracted from patent US 20060287244 A1.
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Cat. No.: HY-177955
CAS No.: 3093625-46-5
Research Areas:  

Neurological Disease

α-Obscurine derivative-1 (Compound 7) is a α-Obscurine (HY-134036) derivative. α-Obscurine derivative-1 inhibits CaV3.1 ion channel current with an IC50 of 0.19 μM. α-Obscurine derivative-1 can be used in the research of neurological disorders .
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Cat. No.: HY-32364
CAS No.: 1029008-71-6
Target:  

Drug Derivative

Research Areas:  

Cancer

3-arylisoquinolinamine derivative is a 3-arylisoquinolinamine derivative with antitumor activity.
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