9925 Results for "

Derivatives

" in MedChemExpress (MCE) Product Catalog:

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171

SBE-β-CD

171 Publications Verification

Cat. No.: HY-17031

CAS No.: 182410-00-0

Synonyms: Sulfobutylether-β-Cyclodextrin

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .

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171

BODIPY 581/591 C11

171 Publications Verification

Cat. No.: HY-D1301

CAS No.: 217075-36-0

BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

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130

Everolimus

130 Cited Publications

Cat. No.: HY-10218

CAS No.: 159351-69-6

Purity: 99.85%

Synonyms: RAD001; SDZ-RAD

Target:

mTOR FKBP Autophagy Apoptosis Bacterial

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective, orally active, blood-brain barrier-permeable mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

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110

FITC

110 Cited Publications

Cat. No.: HY-66019

CAS No.: 3326-32-7

Synonyms: Fluorescein 5-isothiocyanate

Target:

Fluorescent Dye

Research Areas:

Others

FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity and excellent fluorescence quantum yield. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm. In addition, FITC is also a hapten that can induce contact hypersensitivity (CHS) and induce an atopic dermatitis model .

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103

4-Octyl itaconate

103 Cited Publications

Cat. No.: HY-112675

CAS No.: 3133-16-2

Purity: 99.92%

Synonyms: 4-OI

Target:

Keap1-Nrf2

Research Areas:

Inflammation/Immunology

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 .

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101

Carboplatin

101 Cited Publications

Cat. No.: HY-17393

CAS No.: 41575-94-4

Synonyms: NSC 241240

Target:

DNA Alkylator/Crosslinker Autophagy DNA/RNA Synthesis

Research Areas:

Cancer

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

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DHEA

64 Cited Publications

Cat. No.: HY-14650

CAS No.: 53-43-0

Purity: 99.93%

Synonyms: Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone

Category:

Human Gut Microbiota Metabolites Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Environmental Pollutants Endogenous Metabolite Androgen Receptor

DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

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Monomethyl auristatin E

63 Cited Publications

Cat. No.: HY-15162

CAS No.: 474645-27-7

Purity: 99.97%

Synonyms: MMAE; SGD-1010

Target:

Microtubule/Tubulin ADC Payloads Apoptosis

Research Areas:

Cancer

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

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5-Ph-IAA

62 Cited Publications

Cat. No.: HY-134653

CAS No.: 168649-23-8

Purity: 99.51%

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression .

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Sulfo-Cy5 carboxylic acid potassium

50 Cited Publications

Cat. No.: HY-D1374

CAS No.: 1144107-82-3

Sulfo-Cy5 carboxylic acid potassium is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .

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Rhod-2 AM

46 Cited Publications

Cat. No.: HY-D0989

CAS No.: 145037-81-6

Rhod-2 is a high-affinity visible light excitation wavelength Ca ²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm .

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