7 Results for "

Dio1

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "Dio1" in MCE Product Catalog:

3
Propylthiouracil
Propylthiouracil
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3 Cited Publications
Cat. No.: HY-B0346
CAS No.: 51-52-5
Synonyms: 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU
Target:  

Environmental Pollutants Thyroid Hormone Receptor

Research Areas:  

Endocrinology

Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research [1].
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NSC 90469
NSC 90469
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Cat. No.: HY-114557
CAS No.: 1041-01-6
Purity:  99.38%
Synonyms: 3,5-Diiodo-L-thyronine
Category:  

Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:  

JNK NF-κB Sirtuin PGC-1α COX TGF-β Receptor Collagen

NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity [1] .
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DIO1 Human Pre-designed siRNA Set A
DIO1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS03769
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

DIO1 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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4-Di-16-ASP
4-Di-16-ASP
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Cat. No.: HY-133876
CAS No.: 114041-00-8
Purity:  99.76%
Synonyms: DiA
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .
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Propylthiouracil (Standard)
Propylthiouracil (Standard)
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Cat. No.: HY-B0346R
CAS No.: 51-52-5
Synonyms: 6-n-Propylthiouracil (Standard); 6-Propyl-2-thiouracil (Standard); PTU (Standard)
Target:  

Thyroid Hormone Receptor Reference Standards

Research Areas:  

Endocrinology

Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research [1].
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NSC 90469 (Standard)
NSC 90469 (Standard)
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Cat. No.: HY-114557R
CAS No.: 1041-01-6
Synonyms: 3,5-Diiodo-L-thyronine (Standard)
Category:  

Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite

Target:  

Reference Standards COX Sirtuin PGC-1α NF-κB TGF-β Receptor JNK Collagen

NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity [1] .
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DIDO1 Human Pre-designed siRNA Set A
DIDO1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS03767
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

DIDO1 Human Pre-designed siRNA Set A contains three designed siRNAs for DIDO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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