19

Bumetanide

19 Publications Verification

Cat. No.: HY-17468

CAS No.: 28395-03-1

Synonyms: Ro 10-6338; PF 1593

Target:

NKCC

Research Areas:

Cardiovascular Disease Metabolic Disease

Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

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18

D-Mannitol

18 Cited Publications

Cat. No.: HY-N0378

CAS No.: 69-65-8

Synonyms: Mannitol; Mannite

Category:

Natural Products Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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16

Acetazolamide

16 Cited Publications

Cat. No.: HY-B0782

CAS No.: 59-66-5

Target:

Carbonic Anhydrase Autophagy Bacterial

Research Areas:

Cardiovascular Disease Cancer

Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities .

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16

Acetazolamide sodium

16 Cited Publications

Cat. No.: HY-B0782A

CAS No.: 1424-27-7

Target:

Carbonic Anhydrase Autophagy Bacterial

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities .

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11

Furosemide

11 Cited Publications

Cat. No.: HY-B0135

CAS No.: 54-31-9

Target:

GABA Receptor

Furosemide is an orally active GABAA receptor antagonist. Furosemide inhibits carbonic anhydrase, the sodium-chloride cotransporter, sodium reabsorption, tubuloglomerular feedback, and GABA-induced chloride flux. Furosemide can be used as a diuretic reagent. Furosemide is applied in the research of hepatic necrosis, sepsis-associated acute kidney injury, hypoalbuminemia-related fluid retention, and congestive heart failure .

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11

Furosemide sodium

11 Cited Publications

Cat. No.: HY-B0135A

CAS No.: 41733-55-5

Target:

GABA Receptor

Furosemide sodium is an orally active GABAA receptor antagonist. Furosemide sodium inhibits carbonic anhydrase, the sodium-chloride cotransporter, sodium reabsorption, tubuloglomerular feedback, and GABA-induced chloride flux. Furosemide sodium can be used as a diuretic reagent. Furosemide sodium is applied in the research of hepatic necrosis, sepsis-associated acute kidney injury, hypoalbuminemia-related fluid retention, and congestive heart failure .

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10

Ethacrynic acid

10 Cited Publications

Cat. No.: HY-B1640

CAS No.: 58-54-8

Synonyms: Etacrynic acid

Target:

Wnt Glutathione S-transferase NF-κB Calcium Channel NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .

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8

Hydrochlorothiazide

8 Cited Publications

Cat. No.: HY-B0252

CAS No.: 58-93-5

Synonyms: HCTZ

Target:

TGF-beta/Smad Potassium Channel

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

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7

Triamterene

7 Cited Publications

Cat. No.: HY-B0575

CAS No.: 396-01-0

Target:

Sodium Channel G protein-coupled Bile Acid Receptor 1

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Triamterene blocks epithelial Na ⁺ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor .

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7

Urea

7 Cited Publications

Cat. No.: HY-Y0271

CAS No.: 57-13-6

Synonyms: Carbonyl diamide

Category:

Natural Products Microorganisms Endogenous metabolite Disease Research Fields Biological Pesticide Research Cancer Agricultural Research

Target:

Environmental Pollutants Apoptosis Endogenous Metabolite Carbonic Anhydrase ERK

Urea is a powerful protein denaturant via both direct and indirect mechanisms . A potent emollient and keratolytic agent . Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

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6

Cinobufotalin

6 Cited Publications

Cat. No.: HY-N0880

CAS No.: 1108-68-5

Category:

Animals Disease Research Fields Cancer Steroids

Target:

Others

Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent .

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4

Chlorothiazide

4 Cited Publications

Cat. No.: HY-B0224

CAS No.: 58-94-6

Target:

Renin

Research Areas:

Cardiovascular Disease

Chlorothiazide is an orally active diuretic and anti-hypertensive agent .

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3

Azosemide

3 Cited Publications

Cat. No.: HY-107321

CAS No.: 27589-33-9

Purity: 99.85%

Target:

NKCC

Research Areas:

Metabolic Disease

Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC₅₀s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively .

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