68

68 Publications Verification

Target:

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:

Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .

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35

Kanamycin

35 Cited Publications

Cat. No.: HY-16566

CAS No.: 59-01-8

Synonyms: Kanamycin A

Category:

Microorganisms Antibiotics Other Antibiotics

Target:

Antibiotic Bacterial

Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

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35

Kanamycin sulfate

35 Cited Publications

Cat. No.: HY-16566A

CAS No.: 25389-94-0

Synonyms: Kanamycin A sulfate

Category:

Anti-inflammation/Immunoregulatory Disease Research Antibacterial Other Antibiotics Infection Microorganisms Plant Cell Culture Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields

Target:

Bacterial Antibiotic

Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

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25

ML-7 hydrochloride

25 Cited Publications

Cat. No.: HY-15417

CAS No.: 110448-33-4

Purity: 99.60%

Target:

Myosin ERK JNK p38 MAPK Akt Apoptosis Bacterial

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

ML-7 hydrochloride is a selective and highly specific myosin light chain kinase (MLCK) inhibitor that acts as a trabecular meshwork (TM) relaxant. ML-7 hydrochloride enhances Quinocetone (HY-123581)-induced phosphorylation of ERK, p38 MAPK and JNK, attenuates Akt activation, and promotes apoptosis of hepatocellular carcinoma cells. ML-7 hydrochloride reduces Th2 cytokine secretion by inhibiting MLCK, while alleviating smooth muscle hyperplasia and collagen deposition . As a non-antibiotic adjuvant, ML-7 hydrochloride restores the sensitivity of drug-resistant bacteria to Tigecycline (HY-B0117) . ML-7 hydrochloride can be used in research related to glaucoma, hepatocellular carcinoma, asthma, and Klebsiella pneumoniae infection .

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16

Fosfomycin sodium

16 Cited Publications

Cat. No.: HY-W016420

CAS No.: 26016-99-9

Synonyms: MK-0955 sodium

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Bacterial Antibiotic

Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

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16

Fosfomycin calcium

16 Cited Publications

Cat. No.: HY-B1075

CAS No.: 26016-98-8

Synonyms: MK-0955 calcium

Target:

Bacterial Antibiotic

Research Areas:

Infection Cancer

Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

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16

Fosfomycin tromethamine

16 Cited Publications

Cat. No.: HY-B0609

CAS No.: 78964-85-9

Synonyms: MK-0955 tromethamine

Target:

Bacterial Antibiotic

Research Areas:

Infection Cancer

Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

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12

Pretomanid

12 Cited Publications

Cat. No.: HY-10844

CAS No.: 187235-37-6

Purity: 99.97%

Synonyms: PA-824; (S)-PA 824

Target:

Bacterial Antibiotic

Research Areas:

Infection

Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

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7

IR-780

7 Cited Publications

Cat. No.: HY-D1063

CAS No.: 207399-07-3

IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .

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6

Durlobactam sodium

6 Cited Publications

Cat. No.: HY-117974

CAS No.: 1467157-21-6

Purity: 99.62%

Synonyms: ETX2514

Target:

Bacterial

Research Areas:

Infection

Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC₅₀s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii .

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6

DCZ0415

6 Cited Publications

Cat. No.: HY-130603

CAS No.: 2242470-43-3

Purity: 99.81%

Target:

NF-κB Apoptosis

Research Areas:

Cancer

DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients .

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6

Delafloxacin

6 Cited Publications

Cat. No.: HY-14814

CAS No.: 189279-58-1

Purity: 99.95%

Synonyms: RX-3341; WQ-3034; ABT492

Target:

Bacterial Antibiotic

Research Areas:

Infection

Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .

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6

Delafloxacin meglumine

6 Cited Publications

Cat. No.: HY-14814A

CAS No.: 352458-37-8

Purity: 99.87%

Synonyms: ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine

Target:

Bacterial Antibiotic

Research Areas:

Infection

Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .

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4

Sutezolid

4 Cited Publications

Cat. No.: HY-10392

CAS No.: 168828-58-8

Purity: 99.40%

Synonyms: PNU-100480; U-100480; PF-02341272

Target:

Bacterial Antibiotic

Research Areas:

Infection

Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .

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4

SPR719

4 Cited Publications

Cat. No.: HY-12930

CAS No.: 1384984-18-2

Purity: 99.50%

Synonyms: VXc-486

Target:

Topoisomerase Bacterial

Research Areas:

Infection

SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM) .

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4

C6 Ceramide

4 Cited Publications

Cat. No.: HY-19542

CAS No.: 124753-97-5

Synonyms: C6-Cer; N-Hexanoylsphingosine

Target:

Apoptosis

Research Areas:

Cancer

C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

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