631 Results for "

E 2

" in MedChemExpress (MCE) Product Catalog:
Products (631)

631 Results for "E 2" in MCE Product Catalog:

148
Estradiol
Estradiol
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148 Publications Verification
Cat. No.: HY-B0141
CAS No.: 50-28-2
Synonyms: β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
Category:  

Endocrine diseases Endogenous metabolite Monophenols Sunscreen Disease markers Phenols Cosmetic Research Disease Research Fields Cancer Steroids

Target:  

Estrogen Receptor/ERR Endogenous Metabolite Bacterial

Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .
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64
Prostaglandin E2
Prostaglandin E2
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64 Cited Publications
Cat. No.: HY-101952
CAS No.: 363-24-6
Purity:  99.74%
Synonyms: PGE2; Dinoprostone
Category:  

Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Organoid Prostaglandin Receptor Endogenous Metabolite

Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
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27
PYR-41
PYR-41
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27 Cited Publications
Cat. No.: HY-13296
CAS No.: 418805-02-4
Purity:  ≥98.0%
Target:  

E1/E2/E3 Enzyme Apoptosis

Research Areas:  

Cancer

PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with little activity at E2 and E3.
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23
4 Hydroxynonenal Antibody
4 Hydroxynonenal Antibody
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23 Cited Publications
Cat. No.: HY-P81208
Synonyms: 4-Hydroxy-2-Nonenal; 4Hydroxynonenal; 4-Hydroxynonenal; HNE; 4HNE; 4-HNE; (E)-4-Hydroxy-2-nonenal; 2-Nonenal, 4-hydroxy-, (2E)-; (2E)-4-Hydroxy-2-nonenal; 4-Hydroxy-2(E)-nonenal

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, IF-Tissue

Reactivity:  

Species independent

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17
YKL-5-124
YKL-5-124
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17 Cited Publications
Cat. No.: HY-101257
CAS No.: 1957203-01-8
Purity:  98.79%
Target:  

CDK

Research Areas:  

Cancer

YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status .
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17
YKL-5-124 TFA
YKL-5-124 TFA
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17 Cited Publications
Cat. No.: HY-101257B
CAS No.: 2748220-93-9
Purity:  99.74%
Target:  

CDK

Research Areas:  

Cancer

YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status .
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10
HLM006474
HLM006474
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10 Cited Publications
Cat. No.: HY-16667
CAS No.: 353519-63-8
Target:  

Early 2 Factor (E2F)

Research Areas:  

Cancer

HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC50 of 29.8 μM in A375 cells.
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9
TMS
TMS
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9 Cited Publications
Cat. No.: HY-19340
CAS No.: 24144-92-1
Synonyms: (E)-2,3',4,5'-tetramethoxystilbene
Target:  

Cytochrome P450

Research Areas:  

Cancer

TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC50=300 nM) and CYP1A2 (IC50=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity .
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8
NSC697923
NSC697923
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8 Cited Publications
Cat. No.: HY-13811
CAS No.: 343351-67-7
Purity:  99.93%
Target:  

E1/E2/E3 Enzyme Apoptosis

Research Areas:  

Cancer

NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity .
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7
CDDO-EA
CDDO-EA
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7 Cited Publications
Cat. No.: HY-12213
CAS No.: 932730-51-3
Purity:  99.78%
Synonyms: CDDO ethyl amide; TP319; RTA 405
Target:  

Keap1-Nrf2

Research Areas:  

Cancer

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
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7
CGP60474
CGP60474
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7 Cited Publications
Cat. No.: HY-11009
CAS No.: 164658-13-3
Purity:  98.90%
Target:  

CDK PKC

Research Areas:  

Cancer

CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor .
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6
Sulfathiazole
Sulfathiazole
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6 Cited Publications
Cat. No.: HY-B0507
CAS No.: 72-14-0
Target:  

Environmental Pollutants Antibiotic Bacterial

Research Areas:  

Endocrinology Cancer

Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .
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6
Sulfathiazole sodium
Sulfathiazole sodium
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6 Cited Publications
Cat. No.: HY-B0507A
CAS No.: 144-74-1
Target:  

Antibiotic Bacterial

Research Areas:  

Endocrinology Cancer

Sulfathiazole sodium is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole sodium increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole sodium is also a cathodic corrosion inhibitor. It inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively .
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5
4E2RCat
4E2RCat
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5 Cited Publications
Cat. No.: HY-100733
CAS No.: 432499-63-3
Purity:  ≥98.0%
Target:  

Eukaryotic Initiation Factor (eIF) Autophagy Virus Protease

Research Areas:  

Neurological Disease

4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
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5
Cyclosporin H
Cyclosporin H
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5 Cited Publications
Cat. No.: HY-P1122
CAS No.: 83602-39-5
Target:  

Formyl Peptide Receptor (FPR)

Research Areas:  

Infection Inflammation/Immunology

Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
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5
Bimiralisib
Bimiralisib
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5 Cited Publications
Cat. No.: HY-12868
CAS No.: 1225037-39-7
Purity:  98.62%
Synonyms: PQR309
Target:  

PI3K mTOR Apoptosis

Research Areas:  

Cancer

Bimiralisib (PQR309) is an orally active, blood-brain barrier-penetrant PI3K/mTOR inhibitor with in vitro antiproliferative activity and in vivo antitumor activity. Bimiralisib induces G1 cell cycle arrest, apoptosis and cell death in cancer cells, while inhibiting cancer cell proliferation, migration, invasion, colony formation and spheroid generation. Bimiralisib upregulates the expression of E2F4. The combination of Bimiralisib with venetoclax enhances therapeutic efficacy in acute myeloid leukemia models. Bimiralisib can be used in cancer-related research .
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5
Nrf2 Antibody(YA895)
Nrf2 Antibody(YA895)
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5 Cited Publications
Cat. No.: HY-P81051
Synonyms: NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2; like 2

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ChIP

Reactivity:  

Human, Mouse

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4
UbcH5b/UBE2D2 Protein, Human
UbcH5b/UBE2D2 Protein, Human
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4 Cited Publications
Cat. No.: HY-P79449
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2D2; Ubiquitin Conjugating Enzyme E2 D2; UBC4; UbcH5B; Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5); (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D2; P53-Regulated Ubiquitin-Conjugating Enzyme 1; Ubiquitin-Conjugating Enzyme E2-1
Species:  
Human
Source:  
E. coli
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4
Ethyl Caffeate
Ethyl Caffeate
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4 Cited Publications
Cat. No.: HY-N6966
CAS No.: 102-37-4
Category:  

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