26

26 Publications Verification

CAS No.: 51987-99-6

Target:

Research Areas:

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

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26

TGN-020 sodium

26 Publications Verification

Cat. No.: HY-W008574A

CAS No.: 1313731-99-5

Target:

PROTAC Linkers

Research Areas:

Inflammation/Immunology Cancer

TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

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18

D-Mannitol

18 Cited Publications

Cat. No.: HY-N0378

CAS No.: 69-65-8

Synonyms: Mannitol; Mannite

Category:

Natural Products Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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D-Mannitol (Standard)

Cat. No.: HY-N0378R

CAS No.: 69-65-8

Synonyms: Mannitol(Standard); Mannite (Standard)

Category:

Natural Products Microorganisms Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Reference Standards Endogenous Metabolite Apoptosis PGC-1α Adrenergic Receptor PKA

D-Mannitol (Standard) is the analytical standard of D-Mannitol (HY-N0378). This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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Fumonisin B2

Cat. No.: HY-N6723

CAS No.: 116355-84-1

Category:

Infection Human Gut Microbiota Metabolites Microorganisms Antibiotics Disease Research Antibacterial Endogenous metabolite Disease Research Fields Other Antibiotics

Target:

Ceramidase Acyltransferase

Fumonisin B2 is a selective ceramide synthase inhibitor and carcinogenic mycotoxin with toxicity comparable to that of Fumonisin B1 (HY-N6719). Fumonisin B2 inhibits de novo sphingolipid biosynthesis by blocking the amide bond formation between fatty acids and dihydrosphingosine, which leads to a massive intracellular accumulation of free dihydrosphingosine, altered sphingosine levels, subsequent inhibition of cell proliferation, and induction of cell death. Fumonisin B2 is used to investigate the pathogenesis of diseases associated with Fusarium verticillioides contamination, including equine leukoencephalomalacia, porcine pulmonary edema syndrome, human esophageal cancer, and rat hepatocellular carcinoma .

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Tubeimoside II

Cat. No.: HY-N0891

CAS No.: 115810-12-3

Synonyms: Tubeimoside-B

Category:

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Cancer

Target:

EGFR TGF-β Receptor RIG-I-like receptor (RLR) SARS-CoV

Tubeimoside II is an orally active triterpenoid saponin and antiviral agent that binds to PACT/PRKRA with K_d values of 5.37 μM and 133.1 μM, respectively. Tubeimoside II inhibits oxidase-dependent EGFR activation and reduces TGF-β1-induced oxidative stress. Tubeimoside II activates the RIG-I signaling pathway and increases IFN-β secretion. Tubeimoside II suppresses TPA-induced ear edema, mouse sarcoma 180 growth, and TPA-induced skin tumor formation. Tubeimoside II exerts broad-spectrum antiviral activity against SARS-CoV-2, HCoV-OC43, and IAV-H1N1/FM1. Tubeimoside II can be used in research related to retinoblastoma, respiratory viral infections, skin tumors, and sarcoma 180 .

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