17

17 Publications Verification

Category:

Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS) p38 MAPK Akt

Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cancers, cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

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7

Oxybenzone

7 Cited Publications

Cat. No.: HY-A0067

CAS No.: 131-57-7

Synonyms: Benzophenone 3

Target:

Environmental Pollutants Autophagy RAR/RXR Apoptosis

Research Areas:

Neurological Disease

Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

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6

Sulfathiazole

6 Cited Publications

Cat. No.: HY-B0507

CAS No.: 72-14-0

Target:

Environmental Pollutants Antibiotic Bacterial

Research Areas:

Endocrinology Cancer

Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

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6

Sulfathiazole sodium

6 Cited Publications

Cat. No.: HY-B0507A

CAS No.: 144-74-1

Target:

Antibiotic Bacterial

Research Areas:

Endocrinology Cancer

Sulfathiazole sodium is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole sodium increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole sodium is also a cathodic corrosion inhibitor. It inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively .

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3

Bisphenol B

3 Cited Publications

Cat. No.: HY-W013935

CAS No.: 77-40-7

Category:

Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species (ROS)

Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

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3

Triclocarban

3 Cited Publications

Cat. No.: HY-B1805

CAS No.: 101-20-2

Synonyms: 3,4,4′-Trichlorocarbanilide

Target:

Environmental Pollutants Bacterial

Research Areas:

Infection

Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

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2

4-Methylbenzylidene camphor

2 Cited Publications

Cat. No.: HY-17587

CAS No.: 36861-47-9

Synonyms: 4-MBC; Enzacamene

Target:

Apoptosis PI3K Akt ERK

Research Areas:

Metabolic Disease

4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .

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2

4-tert-Octylphenol

2 Cited Publications

Cat. No.: HY-B1941

CAS No.: 140-66-9

Category:

Monophenols Neurological Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Endogenous Metabolite Apoptosis DNA/RNA Synthesis

4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

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1

Dimethyl phthalate

1 Cited Publications

Cat. No.: HY-N7106

CAS No.: 131-11-3

Synonyms: DMP

Category:

Natural Products Microorganisms Animals Other Diseases Plants Other Families Extract Disease Research Fields

Target:

Environmental Pollutants Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS)

Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .

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1

Sulisobenzone

1 Cited Publications

Cat. No.: HY-B1162

CAS No.: 4065-45-6

Synonyms: Benzophenone-4

Target:

Environmental Pollutants Biochemical Assay Reagents

Research Areas:

Metabolic Disease

Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .

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1

Linuron

1 Cited Publications

Cat. No.: HY-B1866

CAS No.: 330-55-2

Target:

Environmental Pollutants Androgen Receptor Herbicide

Research Areas:

Infection Metabolic Disease Cancer

Linuron is a phenylurea herbicide widely used to control the growth of grasses and weeds in various crops and orchards. Linuron acts as a photosystem II inhibitor. It also functions as a competitive androgen receptor (AR) antagonist, with an EC₅₀ of 200 μM and a K_i of 100 μM against rat AR, and an EC₅₀ of 20 μM against human AR. Linuron exhibits reproductive toxicity in animals and acts as an endocrine disruptor .\n

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