8501 Results for "

Endogenous Metabolite

" in MedChemExpress (MCE) Product Catalog:
Products (8501)

8501 Results for "Endogenous Metabolite" in MCE Product Catalog:

1510
Rapamycin
Rapamycin
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1510 Publications Verification
Cat. No.: HY-10219
CAS No.: 53123-88-9
Purity:  99.94%
Synonyms: Sirolimus; AY-22989; NSC 226080
Category:  

Macrolide Antibiotics Anti-inflammation/Immunoregulatory Anti-aging Antibiotics Microorganism Disease Research Disease Research Fields Cancer

Target:  

mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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1371
3-Methyladenine
3-Methyladenine
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1371 Cited Publications
Cat. No.: HY-19312
CAS No.: 5142-23-4
Synonyms: 3-MA
Category:  

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

PI3K Autophagy Mitophagy Endogenous Metabolite

3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .
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784
Acetylcysteine
Acetylcysteine
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784 Cited Publications
Cat. No.: HY-B0215
CAS No.: 616-91-1
Synonyms: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ​​is the most stable form of cysteine ​​during drug delivery and can be used in disulfidptosis studies .
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365
5-Fluorouracil
5-Fluorouracil
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365 Cited Publications
Cat. No.: HY-90006
CAS No.: 51-21-8
Synonyms: 5-FU
Category:  

Natural Products Disease Research Fields Cancer

Target:  

Exosomes Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite

5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .
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234
AICAR
AICAR
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234 Cited Publications
Cat. No.: HY-13417
CAS No.: 2627-69-2
Purity:  99.98%
Synonyms: Acadesine; AICA Riboside
Category:  

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

AMPK Autophagy YAP Mitophagy Endogenous Metabolite

AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .
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234
AICAR phosphate
AICAR phosphate
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234 Cited Publications
Cat. No.: HY-13417A
CAS No.: 681006-28-0
Purity:  99.98%
Synonyms: Acadesine phosphate; AICA Riboside phosphate
Category:  

Alkaloids Other Alkaloids Animal Disease Research Fields Cancer

Target:  

AMPK Autophagy YAP Mitophagy Endogenous Metabolite

AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .
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182
ATP
ATP
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182 Cited Publications
Cat. No.: HY-B2176
CAS No.: 56-65-5
Synonyms: Adenosine 5'-triphosphate
Category:  

Other Families Extract Endogenous metabolite Alkaloids Human Gut Microbiota Metabolites Plant Other Alkaloids Animal Microorganism Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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182
ATP disodium trihydrate
ATP disodium trihydrate
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182 Cited Publications
Cat. No.: HY-B2176A
CAS No.: 51963-61-2
Synonyms: Adenosine-5'-triphosphate disodium trihydrate
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) disodium trihydrate is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation. ATP disodium trihydrate can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium trihydrate has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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182
ATP dimagnesium
ATP dimagnesium
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182 Cited Publications
Cat. No.: HY-B2176B
CAS No.: 74804-12-9
Synonyms: Adenosine 5'-triphosphate dimagnesium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation. ATP dimagnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dimagnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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179
ATP disodium salt
ATP disodium salt
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179 Cited Publications
Cat. No.: HY-B0345A
CAS No.: 987-65-5
Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate
Category:  

Natural Products Plant Animal Other Families Extract Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation .
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175
ATP disodium salt hydrate
ATP disodium salt hydrate
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175 Cited Publications
Cat. No.: HY-W010735
CAS No.: 34369-07-8
Synonyms: Adenosine 5'-triphosphate disodium salt hydrate
Category:  

Plant Ketones, Aldehydes, Acids Animal Other Families Extract Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) disodium salt hydrate is a central component of energy storage and metabolism in vivo. ATP disodium salt hydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt hydrate can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt hydrate has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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172
ATP dipotassium
ATP dipotassium
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172 Cited Publications
Cat. No.: HY-B2176C
CAS No.: 42373-41-1
Synonyms: Adenosine 5'-triphosphate dipotassium
Category:  

Plant Ketones, Aldehydes, Acids Animal Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) dipotassium is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation. ATP dipotassium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dipotassium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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172
ATP magnesium
ATP magnesium
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172 Cited Publications
Cat. No.: HY-B2176E
CAS No.: 1476-84-2
Synonyms: Adenosine 5'-triphosphate magnesium
Target:  

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation. ATP magnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP magnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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172
ATP disodium salt, 100 mM Solution, PCR Grade
ATP disodium salt, 100 mM Solution, PCR Grade
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172 Cited Publications
Cat. No.: HY-B2176I
CAS No.: 987-65-5
Synonyms: Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade
ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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156
Retinoic acid
Retinoic acid
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156 Cited Publications
Cat. No.: HY-14649
CAS No.: 302-79-4
Purity:  99.81%
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
Category:  

Ketones, Aldehydes, Acids Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Cancer

Target:  

Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy

Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
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151
Melatonin
Melatonin
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151 Cited Publications
Cat. No.: HY-B0075
CAS No.: 73-31-4
Synonyms: N-Acetyl-5-methoxytryptamine
Category:  

Natural Products Neurological Disease Other disease Anti-aging Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis PANoptosis Ligands for Target Protein for PROTAC Histone Acetyltransferase

Melatonin is a hormone made by the pineal gland that can activate melatonin receptor and inhibit PANoptosis. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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148
Estradiol
Estradiol
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148 Cited Publications
Cat. No.: HY-B0141
CAS No.: 50-28-2
Synonyms: β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
Category:  

Endocrine diseases Endogenous metabolite Monophenols Sunscreen Disease markers Phenols Cosmetic Research Disease Research Fields Cancer Steroids

Target:  

Estrogen Receptor/ERR Endogenous Metabolite Bacterial

Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .
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148
Estradiol hemihydrate
Estradiol hemihydrate
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148 Cited Publications
Cat. No.: HY-B0141C
CAS No.: 35380-71-3
Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate
Category:  

Endogenous metabolite Steroids

Target:  

Estrogen Receptor/ERR Endogenous Metabolite Bacterial

Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .
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128
Palmitic acid
Palmitic acid
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128 Cited Publications
Cat. No.: HY-N0830
CAS No.: 57-10-3
Category:  

Cardiovascular Disease Natural Products Neurological Disease Other Families Extract Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Plant Animal Microorganism Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite HSP

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .
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128
Palmitic acid sodium
Palmitic acid sodium
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128 Cited Publications
Cat. No.: HY-N0830B
CAS No.: 408-35-5
Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .
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