70

Valproic acid

70 Publications Verification

Cat. No.: HY-10585

CAS No.: 99-66-1

Purity: 99.19%

Synonyms: VPA; 2-Propylpentanoic acid; Dipropylacetic acid

Category:

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

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70

Valproic acid sodium

70 Publications Verification

Cat. No.: HY-10585A

CAS No.: 1069-66-5

Purity: 98.14%

Synonyms: Sodium Valproate; VPA sodium; 2-Propylpentanoic acid sodium

Category:

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

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48

Pilocarpine Hydrochloride

48 Cited Publications

Cat. No.: HY-B0726

CAS No.: 54-71-7

Category:

Alkaloids Other Alkaloids Plants Other Families Extract

Target:

mAChR

Pilocarpine Hydrochloride is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride can induce seizures and is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure .

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48

Pilocarpine

48 Cited Publications

Cat. No.: HY-B0726A

CAS No.: 92-13-7

Target:

mAChR

Research Areas:

Neurological Disease Cancer

Pilocarpine is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine can induce seizures. Pilocarpine is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure .

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48

Pilocarpine nitrate

48 Cited Publications

Cat. No.: HY-B1006

CAS No.: 148-72-1

Category:

Alkaloids Other Alkaloids Plants Other Families Extract

Target:

mAChR

Pilocarpine nitrate is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine nitrate can induce seizures and is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure .

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48

Bicuculline methochloride

48 Cited Publications

Cat. No.: HY-137790

CAS No.: 38641-83-7

Purity: 99.35%

Synonyms: (-)-Bicuculline methochloride

Target:

GABA Receptor

Research Areas:

Neurological Disease

Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC₅₀ value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca ²⁺ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders .

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