1368 Results for "

Epsilon variant

" in MedChemExpress (MCE) Product Catalog:
Products (1368)

1368 Results for "Epsilon variant" in MCE Product Catalog:

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122
Telaglenastat
Telaglenastat
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122 Publications Verification
Cat. No.: HY-12248
CAS No.: 1439399-58-2
Purity:  99.82%
Synonyms: CB-839
Target:  

Glutaminase Autophagy

Research Areas:  

Cancer

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .
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122
Telaglenastat hydrochloride
Telaglenastat hydrochloride
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122 Publications Verification
Cat. No.: HY-12248A
CAS No.: 1874231-60-3
Synonyms: CB-839 hydrochloride
Target:  

Glutaminase Autophagy

Research Areas:  

Cancer

Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity .
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59
Bedaquiline
Bedaquiline
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59 Cited Publications
Cat. No.: HY-14881
CAS No.: 843663-66-1
Purity:  99.98%
Synonyms: TMC207; R207910
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .
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42
BX795
BX795
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42 Cited Publications
Cat. No.: HY-10514
CAS No.: 702675-74-9
Purity:  99.84%
Target:  

PDK-1 IKK Autophagy

Research Areas:  

Cancer

BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy .
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30
Amlexanox
Amlexanox
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30 Cited Publications
Cat. No.: HY-B0713
CAS No.: 68302-57-8
Synonyms: AA673; Amoxanox; CHX3673
Target:  

IKK

Research Areas:  

Metabolic Disease

Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
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30
Grazoprevir
Grazoprevir
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30 Cited Publications
Cat. No.: HY-15298
CAS No.: 1350514-68-9
Purity:  99.99%
Synonyms: MK-5172
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL pro activity .
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30
Grazoprevir potassium salt
Grazoprevir potassium salt
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30 Cited Publications
Cat. No.: HY-15298A
CAS No.: 1206524-86-8
Purity:  99.63%
Synonyms: MK-5172 potassium salt
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL pro activity .
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30
Grazoprevir hydrate
Grazoprevir hydrate
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30 Cited Publications
Cat. No.: HY-15298B
CAS No.: 1350462-55-3
Purity:  99.99%
Synonyms: MK-5172 hydrate
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity .
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29
MRT67307
MRT67307
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29 Cited Publications
Cat. No.: HY-13018
CAS No.: 1190378-57-4
Purity:  99.44%
Target:  

IKK ULK Autophagy

Research Areas:  

Inflammation/Immunology Cancer

MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively . MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells .
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27
Wedelolactone
Wedelolactone
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27 Cited Publications
Cat. No.: HY-N0551
CAS No.: 524-12-9
Category:  

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