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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
F-box
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "F-box" in MCE Product Catalog:
14
14 Publications Verification
Target:
Research Areas:
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities .
7
7 Cited Publications
Synonyms: 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid
Target:
Research Areas:
PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs).
2
2 Cited Publications
Target:
Research Areas:
BC-1215 is a F-box protein 3 (Fbxo3) inhibitor. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 can be used for the research of inflammation .
1
1 Cited Publications
Target:
Research Areas:
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF) Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCF Met30 .
1
1 Cited Publications
BC-1258，an F-box/LRR-repeat protein 2 (FBXL2) activator，can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells，and profoundly inhibits tumor formation in mice .
1
1 Cited Publications
Cat. No.: HY-P81082
Synonyms: Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.
Cat. No.: HY-W1128879
CAS No.: 2271314-01-1
Synonyms: SKPer1
Target:
Research Areas:
XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncoprotein SKP2. XMU-MP-8 simultaneously binds to the F-box domain of SKP2 (Kd ≈ 36 μM) and the N-terminal TPR domain of the E3 ligase STUB1 (Kd ≈ 2.5 μM), forming a stable SKP2-SKPer1-STUB1 ternary complex (Kd ≈ 8.9 nM) that induces SKP2 ubiquitination and proteasomal degradation. XMU-MP-8 selectively eliminates SKP2-expressing cancer cells. XMU-MP-8 exhibits substantial tumour suppression with good safety profiles in vivo. XMU-MP-8 can be used for cancer research, such as non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma .
Cat. No.: HY-P790116
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Atrogin-1; Muscle atrophy F-box protein (MAFbx); FBXO32; F-box only protein 32
Species:
Human
Source:
E. coli
Cat. No.: HY-P790102A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FBXO22; FISTC1; F-box Protein 22; FIST Domain Containing 1; FBX22; F-box Protein FBX22p44; F-box Only Protein 22; TYMAS
Species:
Human
Source:
E. coli
Cat. No.: HY-P706344
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KDM2A; [Histone-H3]-Lysine-36 Demethylase 1A; Prev. FBXL11; CXXC-Type Zinc Finger Protein 8; JHDM1A; Lysine-Specific Demethylase 2A; FBL11; F-box/LRR-Repeat Protein 11; CXXC8; DKFZP434M1735; FBL7; FLJ00115; F-box And Leucine-Rich Repeat Protein 11; [Histone H3]-Dimethyl-L-Lysine(36) Demethylase; KIAA1004; Alternative Protein KDM2A; LILINA; F-box Protein Lilina; JmjC Domain-Containing Histone Demethylation Protein 1A; F-box Protein FBL11; Jumonji C Domain-Containing Histone Demethylase 1A; F-box Protein FBL7; Lysine Demethylase 2A; Lysine (K)-Specific Demethylase 2A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P81525A
Synonyms: FBXW7; FBW7 ; FBX30; SEL10 ; F-box/WD repeat-containing protein 7; F-box protein FBX30; SEL-10; hCdc4
Cat. No.: HY-P701621
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM2A; [Histone-H3]-Lysine-36 Demethylase 1A; Prev. FBXL11; CXXC-Type Zinc Finger Protein 8; JHDM1A; Lysine-Specific Demethylase 2A; FBL11; F-box/LRR-Repeat Protein 11; CXXC8; DKFZP434M1735; FBL7; FLJ00115; F-box And Leucine-Rich Repeat Protein 11; [Histo
Species:
Human
Source:
E. coli
Cat. No.: HY-P701622
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM2A; [Histone-H3]-Lysine-36 Demethylase 1A; Prev. FBXL11; CXXC-Type Zinc Finger Protein 8; JHDM1A; Lysine-Specific Demethylase 2A; FBL11; F-box/LRR-Repeat Protein 11; CXXC8; DKFZP434M1735; FBL7; FLJ00115; F-box And Leucine-Rich Repeat Protein 11; [Histo
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
