20

GLPG0974

20 Publications Verification

Cat. No.: HY-12940

CAS No.: 1391076-61-1

Purity: 98.12%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC₅₀ of 9 nM.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

20

Trimetazidine

20 Publications Verification

Cat. No.: HY-B0968A

CAS No.: 5011-34-7

Target:

Autophagy

Research Areas:

Cardiovascular Disease

Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC₅₀ of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

20

Trimetazidine dihydrochloride

20 Publications Verification

Cat. No.: HY-B0968

CAS No.: 13171-25-0

Target:

Autophagy

Research Areas:

Cardiovascular Disease

Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC₅₀ of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

14

TUG-891

14 Cited Publications

Cat. No.: HY-100881

CAS No.: 1374516-07-0

Purity: 99.47%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

GW9508

9 Cited Publications

Cat. No.: HY-15589

CAS No.: 885101-89-3

Purity: 99.23%

Target:

Free Fatty Acid Receptor Potassium Channel

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC₅₀s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (K_ATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

8

AH-7614

8 Cited Publications

Cat. No.: HY-19996

CAS No.: 6326-06-3

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC₅₀s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC₅₀<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

4-CMTB

6 Cited Publications

Cat. No.: HY-P1125

CAS No.: 300851-67-6

Target:

Free Fatty Acid Receptor

Research Areas:

Others

4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC₅₀=6.38) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

TUG-1375

4 Cited Publications

Cat. No.: HY-112813

CAS No.: 2247372-59-2

Purity: 99.42%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pK_i of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

TUG-770

3 Cited Publications

Cat. No.: HY-15697

CAS No.: 1402601-82-4

Purity: 99.07%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

TUG-770 is a potent, selective and orally active GPR40/FFA1 agonist with an EC₅₀ of 6 nM for human FFA1. TUG-770 shows a high selectivity for FFA1 over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, and enzymes. TUG-770 can be uesd for type 2 diabetes research . TUG-770 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

AMG 837 calcium hydrate

3 Cited Publications

Cat. No.: HY-13967B

CAS No.: 1259389-38-2

Purity: 99.00%

Target:

Bacterial Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

AMG 837 calcium hydrate is an orally active, selective GPR40/FFA1 agonist with an EC₅₀ of 1.5 nM against human GPR40. AMG 837 calcium hydrate stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 calcium hydrate binds to the BacA protein and impairs the survival and replication of Brucella. AMG 837 calcium hydrate can be used in research related to type 2 diabetes and brucellosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

AMG 837

3 Cited Publications

Cat. No.: HY-13967

CAS No.: 865231-46-5

Target:

Free Fatty Acid Receptor Bacterial

Research Areas:

Infection Metabolic Disease

AMG 837 is an orally active, selective GPR40/FFA1 agonist with an EC₅₀ of 1.5 nM against human GPR40. AMG 837 stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 binds to the BacA protein and impairs the survival and replication of Brucella. AMG 837 can be used in research related to type 2 diabetes and brucellosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Acipimox

2 Cited Publications

Cat. No.: HY-B0283

CAS No.: 51037-30-0

Synonyms: K-9321

Target:

Carbonic Anhydrase

Research Areas:

Metabolic Disease

Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity .

Compare

loading...