20 Results for "

FGF-23

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "FGF-23" in MCE Product Catalog:

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FGF-23 Protein, Human
FGF-23 Protein, Human
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2 Cited Publications
Cat. No.: HY-P7013
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF23; FGF-23; Fibroblast Growth Factor 23; HFTC2; Phosphatonin; HPDR2; HYPF; PHPTC; Tumor-Derived Hypophosphatemia Inducing Factor; ADHR; Tumor-Derived Hypophosphatemia-Inducing Factor; FGFN
Species:  
Human
Source:  
E. coli
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Burosumab
Burosumab
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1 Cited Publications
Cat. No.: HY-P9939
CAS No.: 1610833-03-8
Synonyms: KRN23; N5KG1_C10_LH; UX-023

Target:  

Inhibitory Antibodies

Research Areas:  

Metabolic Disease Cancer

Burosumab (KRN23) is a humanized FGF23-neutralizing antibody. By neutralizing FGF23, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia .
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ZINC12409120
ZINC12409120
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Cat. No.: HY-150687
CAS No.: 1010888-06-8
Target:  

ERK

Research Areas:  

Metabolic Disease

ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM .
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T3Inh-1
T3Inh-1
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Cat. No.: HY-125961
CAS No.: 50440-30-7
Purity:  98.82%
Target:  

FGFR Glycosyltransferase

Research Areas:  

Cancer

T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream) .
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SK-124
SK-124
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Cat. No.: HY-173191
CAS No.: 2760404-50-8
Target:  

Salt-inducible Kinase (SIK)

Research Areas:  

Metabolic Disease Endocrinology

SK-124 is an orally active salt-inducible kinase (SIK) inhibitor with an IC50 of 230 nM against SIK1, 4.1 nM against SIK2, and 21 nM against SIK3, exhibiting excellent kinome selectivity . SK-124 blocks SIK-mediated CRTC2 phosphorylation, promotes CRTC2 nuclear translocation, and regulates vitamin D metabolism by upregulating renal Cyp27b1 and downregulating Cyp24a1 . SK-124 upregulates the expression of bone-related genes, increases serum Ca 2+, 1,25-vitamin D and intact FGF23 levels, and suppresses endogenous PTH levels . SK-124 can be used in studies related to osteoporosis, male osteoporosis, and chronic kidney disease-mineral and bone disorder .
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Human FGF23 mRNA
Human FGF23 mRNA
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Cat. No.: HY-174698
Target:  

mRNA

Research Areas:  

Cancer

Human FGF23 mRNA encodes the human fibroblast growth factor 23 (FGF23) protein, a member of the fibroblast growth factor (FGF) family. FGF23 regulates phosphate homeostasis and transport in the kidney.
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3-Ethyltoluene
3-Ethyltoluene
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Cat. No.: HY-W012856
CAS No.: 620-14-4
Synonyms: 3-Methylethylbenzene
Category:  

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