16

Salirasib

16 Publications Verification

Cat. No.: HY-14754

CAS No.: 162520-00-5

Purity: 99.04%

Synonyms: S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS

Target:

Ras Autophagy

Research Areas:

Cancer

Salirasib is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.

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10

Alendronate sodium hydrate

10 Cited Publications

Cat. No.: HY-11101

CAS No.: 121268-17-5

Purity: 99.6%

Synonyms: Alendronate; MK 217; G-704650 Adronat

Target:

Farnesyl Transferase

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC₅₀ of 460 nM.

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7

FTI-277 hydrochloride

7 Cited Publications

Cat. No.: HY-15872A

CAS No.: 180977-34-8

Purity: 98.29%

Target:

Farnesyl Transferase Apoptosis Ras

Research Areas:

Infection Cancer

FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

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6

YM-53601

6 Cited Publications

Cat. No.: HY-100313A

CAS No.: 182959-33-7

Purity: 98.23%

Target:

Farnesyl Transferase HCV

Research Areas:

Infection Metabolic Disease

YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

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4

NE 10790

4 Cited Publications

Cat. No.: HY-16011

CAS No.: 152831-36-2

Synonyms: 3-PEHPC

Target:

Farnesyl Transferase

Research Areas:

Others

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

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2

Risedronic acid

2 Cited Publications

Cat. No.: HY-B0148

CAS No.: 105462-24-6

Synonyms: Risedronate

Target:

Parasite Apoptosis

Research Areas:

Infection Metabolic Disease Cancer

Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

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2

Risedronic acid sodium

2 Cited Publications

Cat. No.: HY-B0119

CAS No.: 115436-72-1

Synonyms: Risedronate sodium

Target:

Parasite Apoptosis

Research Areas:

Infection Metabolic Disease Cancer

Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

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1

Lapaquistat acetate

1 Cited Publications

Cat. No.: HY-16274

CAS No.: 189060-13-7

Synonyms: TAK-475

Target:

Farnesyl Transferase

Research Areas:

Metabolic Disease

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway . Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research .

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1

Farnesyl pyrophosphate ammonium

1 Cited Publications

Cat. No.: HY-113037C

CAS No.: 116057-57-9

Purity: ≥95.0%

Synonyms: Farnesyl diphosphate ammonium

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields

Target:

TRP Channel Endogenous Metabolite Calcium Channel

Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases .

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1

FGTI-2734

1 Cited Publications

Cat. No.: HY-128350

CAS No.: 1247018-19-4

Purity: 99.85%

Target:

Farnesyl Transferase

Research Areas:

Cancer

FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .

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1

FGTI-2734 mesylate

1 Cited Publications

Cat. No.: HY-128350A

CAS No.: 2702297-24-1

Purity: 99.65%

Target:

Farnesyl Transferase γ-Glutamyl Transferase (GGT)

Research Areas:

Cancer

FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .

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1

Ibandronate Sodium Monohydrate

1 Cited Publications

Cat. No.: HY-B0515

CAS No.: 138926-19-9

Synonyms: BM-210955; RPR-102289A

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium Monohydrate can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium Monohydrate inhibits tumor cell proliferation (such as ER ⁺ breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium Monohydrate is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .

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1

Ibandronate Sodium

1 Cited Publications

Cat. No.: HY-B0515B

CAS No.: 138844-81-2

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Ibandronate Sodium is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium inhibits tumor cell proliferation (such as ER+ breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .

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