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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
172 Results for "
Fatty Acid Synthesis
" in MedChemExpress (MCE) Product Catalog:
Products (172)
172 Results for "Fatty Acid Synthesis" in MCE Product Catalog:
48
48 Publications Verification
Cat. No.: HY-50662
CAS No.: 844499-71-4
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A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .
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24
24 Cited Publications
Cat. No.: HY-W018392
CAS No.: 4376-20-9
Synonyms: MEHP; Phthalic Acid mono-2-ethylhexyl ester
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13
13 Cited Publications
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CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .
13
13 Cited Publications
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CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .
12
12 Cited Publications
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TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth .
11
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
6
6 Cited Publications
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TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression .
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3
2
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UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections[1][2][3].
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2 Cited Publications
Synonyms: Heptanedioic Acid; 1,5-Pentanedicarboxylic Acid; 1,7-Heptanedioic Acid
Category:
Immune System Disorder Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
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2
2 Cited Publications
Synonyms: O-Acetyl-L-carnitine; ALCAR
Category:
2
2 Cited Publications
Synonyms: O-Acetyl-L-carnitine hydrochloride; ALCAR hydrochloride
Category:
1
1
1 Cited Publications
Cat. No.: HY-N2486
CAS No.: 30197-14-9
Category:
Plant Monophenols Rheum rhabarbarum Linnaeus Extract Stilbenes Rheum tanguticum Extract Phenols Disease Research Fields Polygonaceae Extract Cancer
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1
1 Cited Publications
Cat. No.: HY-W015580
CAS No.: 4695-62-9
1
1
1 Cited Publications
Cat. No.: HY-W018392S
CAS No.: 1276197-22-8
Synonyms: MEHP-d4; Phthalic Acid mono-2-ethylhexyl ester-d4
1
1 Cited Publications
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
