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30 Results for "

FoxO3a

" in MedChemExpress (MCE) Product Catalog:

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Ipatasertib

71 Publications Verification

Cat. No.: HY-15186

CAS No.: 1001264-89-6

Purity: 99.79%

Synonyms: GDC-0068; RG7440

Target:

Organoid Akt Apoptosis

Research Areas:

Cancer

Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

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Dordaviprone

10 Cited Publications

Cat. No.: HY-15615A

CAS No.: 1616632-77-9

Purity: 99.89%

Synonyms: TIC10; ONC-201

Target:

TNF Receptor Apoptosis

Research Areas:

Cancer

Dordaviprone (TIC10) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. Dordaviprone can cross the blood-brain barrier .

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Butein

7 Cited Publications

Cat. No.: HY-16558

CAS No.: 487-52-5

Synonyms: 2’,3,4,4’-tetrahydroxy Chalcone

Category:

Flavonoids Chalcones Anti-aging Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:

EGFR Autophagy Apoptosis Phosphodiesterase (PDE)

Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

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PhosTAC7

5 Cited Publications

Cat. No.: HY-145232

CAS No.: 3016307-75-5

Purity: 98.76%

Synonyms: OGTAC-3

Target:

PhosTACs Phosphatase Tau Protein

Research Areas:

Neurological Disease Cancer

PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases (Alzheimer's disease) .

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