24 Results for "

GAS6

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "GAS6" in MCE Product Catalog:

10
LDC1267
LDC1267
0 Images
10 Publications Verification
Cat. No.: HY-12494
CAS No.: 1361030-48-9
Purity:  99.64%
Target:  

TAM Receptor FLT3

Research Areas:  

Neurological Disease Cancer

LDC1267 is a AXL/TAM/FLT3 inhibitor with IC50 values of 42 nM, 130 nM, and 63 nM against AXL, MERTK, and TYRO3, respectively. LDC1267 blocks GAS6-induced AXL phosphorylation and the downstream AKT/ERK1/2 signaling pathway. LDC1267 inhibits cancer cell proliferation, colony formation, and glioblastoma cell invasion, without causing obvious impairment of cytotoxic autophagic flux. LDC1267 exerts a synergistic effect when used in combination with Imatinib (HY-15463) in chronic myeloid leukemia models. LDC1267 can be widely applied in studies related to glioblastoma and chronic myeloid leukemia .
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3
GAS6 Protein, Human (HEK293, His, solution)
GAS6 Protein, Human (HEK293, His, solution)
0 Images
3 Cited Publications
Cat. No.: HY-P70780
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AXLLG; DKFZp666G247; AXL Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; AXL Stimulatory Factor
Species:  
Human
Source:  
HEK293
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2
Batiraxcept
Batiraxcept
0 Images
2 Cited Publications
Cat. No.: HY-P99463
CAS No.: 2268717-61-7
Synonyms: AVB-500; AVB-S6-500

Target:  

TAM Receptor PI3K Akt p38 MAPK

Research Areas:  

Cancer

Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((KD <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .
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1
Poricoic acid A
Poricoic acid A
0 Images
1 Cited Publications
Cat. No.: HY-N2995
CAS No.: 137551-38-3
Synonyms: Poricoic acid A(F)
Category:  

Triterpenes Terpenoids Polyporaceae Extract 500 - Internal Server Error | MedChemExpress

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