86 Results for "

GBM

" in MedChemExpress (MCE) Product Catalog:
Products (86)

86 Results for "GBM" in MCE Product Catalog:

8
Mebendazole
Mebendazole
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8 Publications Verification
Cat. No.: HY-17595
CAS No.: 31431-39-7
Target:  

Parasite Apoptosis Microtubule/Tubulin

Research Areas:  

Infection Cancer

Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration .
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7
N1,N11-Diethylnorspermine tetrahydrochloride
N1,N11-Diethylnorspermine tetrahydrochloride
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7 Cited Publications
Cat. No.: HY-13610A
CAS No.: 156886-85-0
Purity:  99.82%
Synonyms: Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride
Target:  

Caspase mTOR

Research Areas:  

Cancer

N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
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5
VX-984
VX-984
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5 Cited Publications
Cat. No.: HY-19939S
CAS No.: 1476074-39-1
Synonyms: M9831
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .
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4
Tesevatinib
Tesevatinib
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4 Cited Publications
Cat. No.: HY-13314
CAS No.: 781613-23-8
Purity:  99.41%
Synonyms: XL-647; EXEL-7647; KD-019
Target:  

EGFR VEGFR Src

Research Areas:  

Cancer

Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity .
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3
Silevertinib
Silevertinib
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3 Cited Publications
Cat. No.: HY-153268
CAS No.: 2607829-38-7
Purity:  99.03%
Synonyms: BDTX-1535; EGFR-IN-76
Target:  

EGFR

Research Areas:  

Infection Neurological Disease Metabolic Disease Cancer

Silevertinib (BDTX-1535) is an irreversible, brain-penetrant, selective and orally active EGFR inhibitor with wild-type EGFR-sparing. Silevertinib targets key EGFR resistance mutations, including the kinase domain (C797S, L718Q, G724S, S768I), extracellular domain (EGFRvIII, A289X), and EGFR amplification. Silevertinib exerts anti-tumor activity with well tolerated in vivo. Silevertinib can be used for non-small cell lung cancer (NSCLC) and glioblastoma (GBM) research .
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2
INDY
INDY
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2 Cited Publications
Cat. No.: HY-108476
CAS No.: 1169755-45-6
Purity:  99.32%
Target:  

DYRK

Research Areas:  

Cancer

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells .
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2
Isolinderalactone
Isolinderalactone
0 Images
2 Cited Publications
Cat. No.: HY-N3001
CAS No.: 957-66-4
Category:  

Lauraceae Extract Terpenoids Sesquiterpenes Plants Disease Research Fields 500 - Internal Server Error | MedChemExpress

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