40

Rhosin hydrochloride

40 Publications Verification

Cat. No.: HY-12646

CAS No.: 1281870-42-5

Purity: 99.93%

Target:

Ras Apoptosis

Research Areas:

Cancer

Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis . Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

40

Rhosin

40 Publications Verification

Cat. No.: HY-12646A

CAS No.: 1173671-63-0

Purity: 95.08%

Target:

Ras Apoptosis

Research Areas:

Cancer

Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis . Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

7

Y16

7 Cited Publications

Cat. No.: HY-12649

CAS No.: 429653-73-6

Purity: 98.10%

Target:

Ras

Research Areas:

Cancer

Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a K_d value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

ESI-05

5 Cited Publications

Cat. No.: HY-117656

CAS No.: 5184-64-5

Purity: 99.78%

Synonyms: NSC 116966

Target:

Acyltransferase

Research Areas:

Neurological Disease Metabolic Disease

ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC₅₀ of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

CPYPP

3 Cited Publications

Cat. No.: HY-110100

CAS No.: 310460-39-0

Purity: 99.94%

Target:

DOCK

Research Areas:

Inflammation/Immunology

CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2 ^DHR-2 for Rac1 in a dose-dependent manner with an IC₅₀ of 22.8 µM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9 .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

BAY-293

2 Cited Publications

Cat. No.: HY-114398

CAS No.: 2244904-70-7

Purity: 98.97%

Target:

SOS1 Ras

Research Areas:

Cancer

BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC₅₀ of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

ITX3

2 Cited Publications

Cat. No.: HY-16663

CAS No.: 347323-96-0

Target:

ROCK

Research Areas:

Others

ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC₅₀ value of 76 μM. ITX3 can be used for the research of agent .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

ZINC69391

1 Cited Publications

Cat. No.: HY-102078

CAS No.: 303094-67-9

Purity: 99.76%

Target:

Ras Apoptosis

Research Areas:

Cancer

ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

LUNA18

Cat. No.: HY-156002

CAS No.: 2676177-63-0

Purity: 99.20%

Synonyms: Paluratide

Target:

Ras ERK

Research Areas:

Cancer

LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors (GEFs) in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

BI-2852

Cat. No.: HY-126247

CAS No.: 2375482-51-0

Purity: 99.57%

Target:

Ras

Research Areas:

Cancer

BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

Compare

loading...