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36 Results for "

GLI1

" in MedChemExpress (MCE) Product Catalog:

Products (36)

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GANT 61

69 Publications Verification

Cat. No.: HY-13901

CAS No.: 500579-04-4

Purity: 99.66%

Synonyms: NSC 136476

Target:

Gli Autophagy

Research Areas:

Cancer

GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

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August 31

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GANT 58

9 Cited Publications

Cat. No.: HY-13282

CAS No.: 64048-12-0

Purity: 99.37%

Synonyms: NSC 75503

Target:

MOFs Gli

Research Areas:

Cancer

GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC₅₀ of 5 μM ^[1].

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Taladegib

2 Cited Publications

Cat. No.: HY-13242

CAS No.: 1258861-20-9

Purity: 99.92%

Synonyms: LY2940680

Target:

Smo Gli

Research Areas:

Cancer

Taladegib is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC₅₀ of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC₅₀ of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers ^[1] .

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