35

Sitagliptin

35 Publications Verification

Cat. No.: HY-13749

CAS No.: 486460-32-6

Purity: 99.75%

Synonyms: MK-0431

Target:

Dipeptidyl Peptidase GLP Receptor PKA ERK

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sitagliptin (MK-0431) is an orally active and highly selective DPP4 inhibitor with an IC₅₀ value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes .

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35

Sitagliptin phosphate

35 Publications Verification

Cat. No.: HY-13749A

CAS No.: 654671-78-0

Purity: 99.79%

Synonyms: MK-0431 phosphate

Target:

PKA ERK GLP Receptor Dipeptidyl Peptidase

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Sitagliptin (MK-0431) phosphate is an orally active and highly selective DPP4 inhibitor with an IC₅₀ value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes .

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35

Sitagliptin phosphate monohydrate

35 Publications Verification

Cat. No.: HY-13749B

CAS No.: 654671-77-9

Purity: 99.83%

Synonyms: MK-0431 phosphate monohydrate

Target:

GLP Receptor Dipeptidyl Peptidase PKA ERK

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Sitagliptin (MK-0431) phosphate monohydrate is an orally active and highly selective DPP4 inhibitor with an IC₅₀ value of 19 nM. Sitagliptin phosphate monohydrate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate monohydrate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate monohydrate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate monohydrate can be used for the study of 1-type and 2-type diabetes .

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29

Tirzepatide sodium

29 Cited Publications

Cat. No.: HY-P1731C

Synonyms: LY3298176 sodium

Target:

GLP Receptor Insulin Receptor Apoptosis mTOR

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .

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4

Lixisenatide

4 Cited Publications

Cat. No.: HY-P0119

CAS No.: 320367-13-3

Target:

GLP Receptor Akt MEK Apoptosis Reactive Oxygen Species (ROS) MMP

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis .

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4

Lixisenatide acetate

4 Cited Publications

Cat. No.: HY-P0119A

CAS No.: 1997361-87-1

Target:

GLP Receptor Akt MEK Reactive Oxygen Species (ROS) Apoptosis MMP

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Lixisenatide acetate is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide acetate inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide acetate can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide acetate can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis .

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1

2-Oleoylglycerol

1 Cited Publications

Cat. No.: HY-W011121

CAS No.: 3443-84-3

Synonyms: 2-OG

Category:

Human Gut Microbiota Metabolites Metabolic Disease Lipids Endogenous metabolite Disease Research Fields

Target:

GPR119 NF-κB TGF-beta/Smad GLP Receptor

2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC₅₀ value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) .

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