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18 Results for "

GLUT-2

" in MedChemExpress (MCE) Product Catalog:

Products (18)

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162

Streptozotocin

162 Publications Verification

Cat. No.: HY-13753

CAS No.: 18883-66-4

Purity: 99.20%

Synonyms: Streptozocin; NSC-85998; U 9889

Category:

Microorganisms Antibiotics Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:

DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells ^[2] .

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BAY-876

63 Cited Publications

Cat. No.: HY-100017

CAS No.: 1799753-84-6

Purity: 99.67%

Target:

GLUT Disulfidptosis

Research Areas:

Cancer

BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC₅₀ of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis ^[2] .

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KL-11743

8 Cited Publications

Cat. No.: HY-145597

CAS No.: 1369452-53-8

Purity: 99.40%

Target:

GLUT Disulfidptosis

Research Areas:

Metabolic Disease Cancer

KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC₅₀s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis ^[2] .

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MSNBA

2 Cited Publications

Cat. No.: HY-W179181

CAS No.: 852702-51-3

Target:

GLUT

Research Areas:

Metabolic Disease Cancer

MSNBA is a potent and selective GLUT5 fructose transport inhibitor with an IC₅₀ of 0.10 mM. MSNBA does not affect the transport activity of human GLUT1, GLUT2, GLUT3, GLUT4 or bacterial GlcPSe. MSNBA competitively inhibits GLUT5 fructose uptake with a K_i of 3.2 μM in MCF7 cells. MSNBA can be used for the study of cancer or diabetes .

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