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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
GM1
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "GM1" in MCE Product Catalog:
8
8 Cited Publications
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Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM [1].
8
8 Cited Publications
Cat. No.: HY-12744A
CAS No.: 943344-58-9
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Genz-123346 is a potent, orally available glucosylceramide synthase inhibitor. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 value of 14 nM [1].
Cat. No.: HY-N10546
CAS No.: 37758-47-7
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Cat. No.: HY-P990025
CAS No.: 2579031-19-7
Synonyms: ARGX-117
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Cat. No.: HY-N10546A
CAS No.: 1007119-81-4
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Ganglioside GM1 (bovine) ammonium is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 (bovine) ammonium exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and ERK1/2, and inhibiting oxidative stress and cell apoptosis and autophagy. Ganglioside GM1 (bovine) ammonium can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease [1] .
Cat. No.: HY-P10529
CAS No.: 247185-97-3
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Cat. No.: HY-W714151
CAS No.: 71012-19-6
Synonyms: Gg4cer; Asialoganglioside GM1; Asialo GM1, Gangliotetraosylceramide; Asialo ganglioside GM1a [...]; Ganglio-n-tetraosylceramide; Asialo GM1 ganglioside; Asialoganglioside gt1b
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Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.
Cat. No.: HY-131931
CAS No.: 171483-40-2
Synonyms: LysoGM1 potassium
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Lysoganglioside-GM1 (LysoGM1) potassium is a derivative of Monosialoganglioside GM1, which lacks a fatty acid. Lysoganglioside-GM1 potassium is also an inhibitor of GM1 aggregation. Lysoganglioside-GM1 potassium can inhibit the activation of Lyn and laminin-1-mediated neurite outgrowth. Lysoganglioside-GM1 potassium can be used in the research of nervous system diseases [1].
Cat. No.: HY-171936
CAS No.: 1329115-44-7
Synonyms: GM1 (d18:1/C18:0) ammonium; C18 Ganglioside GM1 (d18:1/18:0) ammonium
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Ganglioside GM1 (ammonium) is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 (ammonium) is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 (ammonium) exhibits anti-inflammatory property. Ganglioside GM1 (ammonium) has a well-balanced amphiphilic behavior. Ganglioside GM1 (ammonium) can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 (ammonium) can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 (ammonium) can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 (ammonium) can be studied in neurodegenerative diseases such as Alzheimer’s disease [1] .
Cat. No.: HY-146876S
CAS No.: 2260669-93-8
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C18:0 GM1 Ganglioside-d5 (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).
Cat. No.: HY-E70050
CAS No.: 37217-28-0
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beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase) is an enzyme that required for sialylated lipooligosaccharide (LOS SIAL) production, is often used in biochemical studies. beta-1,3-Galactosyltransferase (CgtB) catalyzes the addition of a galactose molecule, which is required for GM1-like LOS SIAL structure production [1].
Cat. No.: HY-131931A
Synonyms: LysoGM1 ammonium
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Lysoganglioside-GM1 (LysoGM1) ammonium is a derivative of Monosialoganglioside GM1, which lacks a fatty acid. Lysoganglioside-GM1 ammonium is also an inhibitor of GM1 aggregation. Lysoganglioside-GM1 ammonium can inhibit the activation of Lyn and laminin-1-mediated neurite outgrowth. Lysoganglioside-GM1 ammonium can be used in the research of nervous system diseases [1].
Cat. No.: HY-E70073
CAS No.: 2170331-76-5
Synonyms: Sialidase isoenzyme M2; AuSialidase M2
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Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate [1].
Cat. No.: HY-N10511
CAS No.: 67063-78-9
Category:
Natural Products Polysaccharides Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides
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Cat. No.: HY-N15820
CAS No.: 3056013-75-0
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C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0) is a ganglioside.
Cat. No.: HY-N16332
CAS No.: 94458-59-0
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Cat. No.: HY-N15959
CAS No.: 2707415-24-3
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Photoclick GM1 ammonium is a clickable sphingolipid.
Cat. No.: HY-N16224
CAS No.: 2456348-97-1
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12:0 Pyrene GM1 (ammonium) is a sphosphingolipid.
Cat. No.: HY-167593S
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C18:0-d7 GM1 Ceramide is deuterium labeled C18:0 GM1 Ceramide [1].
Cat. No.: HY-179767
CAS No.: 2456349-02-1
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C17:0 GM1 ammonium is a glycosphingolipid.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
