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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
GMPPNP
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "GMPPNP" in MCE Product Catalog:
Cat. No.: HY-W1126235
CAS No.: 2253733-45-6
Synonyms: D223
Target:
Research Areas:
DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research .
Cat. No.: HY-153663
CAS No.: 2847881-81-4
TH-Z827 is a selective KRAS G12D inhibitor that exhibits activity against GDP-bound and GMPPNP-bound KRAS G12D, but shows no activity against KRAS (WT) and KRAS G12C. TH-Z827 blocks the KRAS G12D-CRAF interaction with a IC50 value of 42 μM. TH-Z827 can be used for the research of pancreatic cancer .
Cat. No.: HY-179403
CAS No.: 2966924-23-0
KRASG12C IN-17 is an orally active covalent KRAS G12C inhibitor, showing strong inhibitory activity in KRAS G12C-mutant cancer cells (NCI-H23 IC50 = 0.7 nM; NCI-H358 IC50 = 0.5 nM).
KRASG12C IN-17 covalently and irreversibly binds to KRAS G12C with > 96% modification efficiency in both GDP-bound and GMPPNP-bound conformations.
KRASG12C IN-17 can be used for studies of KRAS-driven cancers, including colorectal cancer .
Cat. No.: HY-153663B
TH-Z827 diTFA is a selective KRAS G12D inhibitor that exhibits activity against GDP-bound and GMPPNP-bound KRAS G12D, but shows no activity against KRAS (WT) and KRAS G12C. TH-Z827 diTFA blocks the KRAS G12D-CRAF interaction with a IC50 value of 42 μM. TH-Z827 diTFA can be used for the research of pancreatic cancer .
Cat. No.: HY-187330
Target:
Research Areas:
Anticancer agent 356 is a phthaloyl derivative with anticancer activity. Molecular docking results of Anticancer agent 356 show that it binds to the EGFR tyrosine kinase domain, KRIT1-Rap1-HEG1 ternary complex and EF-Pyl-GMPPNP complex, thereby stabilizing the complexes and reducing the flexibility of residues at the binding sites. Anticancer agent 356 exhibits cytotoxicity against prostate cancer cells and breast cancer cells. Anticancer agent 356 can be used in the research of prostate cancer and breast cancer .
Cat. No.: HY-189619
BRSD-212 is an orally active KRAS G12V/G12D inhibitor. BRSD-212 binds the switch-II pocket and inhibits GDP- and GMPPNP-bound mutant KRAS, with IC50 <0.2 nM for both variants. BRSD-212 inhibits ERK phosphorylation in KRAS-mutant tumor cell lines. BRSD-212 induces tumor regression and inhibits tumor growth in xenograft models. BRSD-212 is well tolerated in murine tumor models with no body weight change. BRSD-212 can be used for the research of cancer .
Cat. No.: HY-179404
CAS No.: 2966924-24-1
KRASG12C IN-18 is an orally active covalent KRAS G12C inhibitor that achieves complete covalent engagement of KRAS G12C in both GDP- and GMPPNP-bound states and displays strong antiproliferative activity against KRAS G12C and resistance-associated variants, including KRAS G12C/R68S, with low-nanomolar IC50 values.
KRASG12C IN-18 exhibits marked in vivo efficacy in KRAS G12C-driven solid tumor and KRAS G12C/R68S xenograft models and can be used for colorectal cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
