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66 Results for "

GO

" in MedChemExpress (MCE) Product Catalog:

Products (66)

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Go 6983

94 Publications Verification

Cat. No.: HY-13689

CAS No.: 133053-19-7

Purity: 99.32%

Synonyms: Gö 6983; GOe 6983

Target:

PKC

Research Areas:

Cancer

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

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Bisindolylmaleimide I

46 Cited Publications

Cat. No.: HY-13867

CAS No.: 133052-90-1

Purity: 98.15%

Synonyms: GF109203X; GO 6850

Target:

PKC GSK-3

Research Areas:

Metabolic Disease Cancer

Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor .

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Bisindolylmaleimide I hydrochloride

46 Cited Publications

Cat. No.: HY-13867A

CAS No.: 176504-36-2

Purity: 99.18%

Synonyms: GF109203X hydrochloride; GO 6850 hydrochloride

Target:

PKC GSK-3

Research Areas:

Metabolic Disease Cancer

Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor .

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Branaplam

18 Cited Publications

Cat. No.: HY-19620

CAS No.: 1562338-42-4

Synonyms: LMI070; NVS-SM1

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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Branaplam hydrochloride

18 Cited Publications

Cat. No.: HY-19620A

CAS No.: 1562338-39-9

Synonyms: LMI070 hydrochloride; NVS-SM1 hydrochloride

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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