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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
81 Results for "
GPC3 knockdown
" in MedChemExpress (MCE) Product Catalog:
Products (81)
81 Results for "GPC3 knockdown" in MCE Product Catalog:
4
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Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [ 3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [ 3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks [3].
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Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (Kd of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth [3] .
1
1 Cited Publications
Cat. No.: HY-161719
CAS No.: 3083634-54-9
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NF764 is a CTNNB1 degrader. When used in combination with USP38 knockdown, NF764 exhibits synergistic anti-tumor activity and induces Ferroptosis. NF764 can be used in studies related to colorectal cancer and melanoma .
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1 Cited Publications
Cat. No.: HY-161766
CAS No.: 2776151-36-9
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L687 is an activator of TRPC3, TRPC6, and TRPC7 cation channels and induces calcium influx. L687 induces macropinocytosis and endocytosis. L687 enhances cellular uptake and knockdown activity of antisense oligonucleotides. L687 alone does not alter SRRM4 expression. L687 can be used for research on small cell lung cancer .
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1 Cited Publications
Cat. No.: HY-P70487
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GPC3; SGB; Prev. SDYS; Glypican Proteoglycan 3; Glypican-3; GTR2-2; OCI-5; MXR7; SGBS1; Heparan Sulphate Proteoglycan; SGBS; Secreted Glypican-3; DGSX; OCI5; Glypican 3; Intestinal Protein OCI-5
Species:
Human
Source:
HEK293
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MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells .
Cat. No.: HY-W1124925
CAS No.: 3066439-94-6
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Cat. No.: HY-P5423
CAS No.: 107658-43-5
Cat. No.: HY-P10888A
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Cat. No.: HY-W587427
CAS No.: 70195-25-4
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D-2-Phosphoglyceric acid trisodium is a glycolysis and gluconeogenesis intermediate with altered levels linked to MCT4-modulated glycolytic pathways. D-2-Phosphoglyceric acid trisodium shows reduced intracellular levels in hypoxic glioblastoma stem cells after MCT4 knockdown. D-2-Phosphoglyceric acid trisodium can be used for the research of glioblastoma .
Cat. No.: HY-P10888
CAS No.: 3066113-41-2
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Cat. No.: HY-P990841
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Synonyms: BRD5846
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BAY-888 is a selective CK1α/CSNK1A1 (casein kinase 1α) ATP-competitive inhibitor (IC50: 4 nM@10 μM ATP; 63 nM@1 mM ATP). BAY-888 blocks the negative regulation of p53 and other signaling pathways by CK1α, induces apoptosis and inhibits proliferation of tumor cells. BAY-888 has shown inhibitory efficacy against cancers such as acute myeloid leukemia (AML) in PRISM barcoded cell line screening and can mimic the effects of shRNA-mediated CK1α knockdown. BAY-888 is primarily used for the development of anticancer drugs for p53 wild-type tumors and for the study of the mechanisms of CK1α-related signaling pathways [3].
Cat. No.: HY-P990840
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Cat. No.: HY-159692
CAS No.: 2603457-08-3
Synonyms: IONIS-1063734
AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .
Cat. No.: HY-B0874
CAS No.: 67375-30-8
Synonyms: FMC 45497; Fendona; WL 85871
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Alpha-Cypermethrin (FMC 45497; Fendona; WL 85871) is a type II pyrethroid insecticide. Alpha-Cypermethrin acts by delaying the inactivation of voltage-gated sodium channels, prolonging sodium tail currents, and triggering repetitive neural discharges. Alpha-Cypermethrin exhibits knockdown and lethal activity against target insects such as Musca domestica and Anopheles culicifacies. Alpha-Cypermethrin induces neurotoxicity in mammals, alters placental and fetal neurodevelopment, and causes acute mortality in fish. Alpha-Cypermethrin can be used in studies related to neurotoxicity, vector-borne diseases, and malaria [3] .
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β-NF-JQ1 is a BRD2/3/4 PROTAC degrader. β-NF-JQ1 recruits the AhR E3 ligase complex to BRD2, BRD3 and BRD4, induces AhR-BRD interaction, and mediates AhR-dependent degradation through the proximity effect between the target protein and AhR. β-NF-JQ1 acts as an antiproliferative and cytotoxic agent that induces anticancer activity associated with BRD protein knockdown. β-NF-JQ1 can be used for research on breast cancer and neuroblastoma .
Cat. No.: HY-RS05628
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GPC3 Human Pre-designed siRNA Set A contains three designed siRNAs for GPC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16630
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Gpc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
