17

Fasiglifam

17 Publications Verification

Cat. No.: HY-10480

CAS No.: 1000413-72-8

Purity: 98.97%

Synonyms: TAK-875

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC₅₀ of 72 nM.

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9

GW9508

9 Cited Publications

Cat. No.: HY-15589

CAS No.: 885101-89-3

Purity: 99.23%

Target:

Free Fatty Acid Receptor Potassium Channel

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC₅₀s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (K_ATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities .

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3

SCO-267

3 Cited Publications

Cat. No.: HY-132265

CAS No.: 1656261-09-4

Purity: 99.88%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes .

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3

TUG-770

3 Cited Publications

Cat. No.: HY-15697

CAS No.: 1402601-82-4

Purity: 99.07%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

TUG-770 is a potent, selective and orally active GPR40/FFA1 agonist with an EC₅₀ of 6 nM for human FFA1. TUG-770 shows a high selectivity for FFA1 over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, and enzymes. TUG-770 can be uesd for type 2 diabetes research . TUG-770 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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3

AM-1638

3 Cited Publications

Cat. No.: HY-13467

CAS No.: 1142214-62-7

Purity: 99.65%

Target:

Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

AM-1638 is an orally active full agonist of GPR40 (EC₅₀: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%) .

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3

AMG 837 calcium hydrate

3 Cited Publications

Cat. No.: HY-13967B

CAS No.: 1259389-38-2

Purity: 99.00%

Target:

Bacterial Free Fatty Acid Receptor

Research Areas:

Metabolic Disease

AMG 837 calcium hydrate is an orally active, selective GPR40/FFA1 agonist with an EC₅₀ of 1.5 nM against human GPR40. AMG 837 calcium hydrate stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 calcium hydrate binds to the BacA protein and impairs the survival and replication of Brucella. AMG 837 calcium hydrate can be used in research related to type 2 diabetes and brucellosis .

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3

AMG 837

3 Cited Publications

Cat. No.: HY-13967

CAS No.: 865231-46-5

Target:

Free Fatty Acid Receptor Bacterial

Research Areas:

Infection Metabolic Disease

AMG 837 is an orally active, selective GPR40/FFA1 agonist with an EC₅₀ of 1.5 nM against human GPR40. AMG 837 stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 binds to the BacA protein and impairs the survival and replication of Brucella. AMG 837 can be used in research related to type 2 diabetes and brucellosis .

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