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37 Results for "

GST-P

" in MedChemExpress (MCE) Product Catalog:

Products (37)

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Ezatiostat

7 Publications Verification

Cat. No.: HY-13634A

CAS No.: 168682-53-9

Purity: 99.71%

Synonyms: TER199free base; TLK199

Target:

Glutathione S-transferase Apoptosis

Research Areas:

Cancer

Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .

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NBDHEX

3 Cited Publications

Cat. No.: HY-135318

CAS No.: 787634-60-0

Purity: 98.56%

Target:

Apoptosis Autophagy Glutathione S-transferase

Research Areas:

Cancer

NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .

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GSTO-IN-2

2 Cited Publications

Cat. No.: HY-112534

CAS No.: 1202710-57-3

Purity: ≥98.0%

Target:

Glutathione S-transferase

Research Areas:

Cancer

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC₅₀s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

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LAS17

1 Cited Publications

Cat. No.: HY-115673

CAS No.: 2362527-67-9

Purity: 97.46%

Target:

Glutathione S-transferase

Research Areas:

Cancer

LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) . LAS17 inhibits GSTP1 activity with an IC₅₀ of 0.5 μM . LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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TLK117

1 Cited Publications

Cat. No.: HY-13634B

CAS No.: 152684-53-2

Purity: 99.89%

Synonyms: TER117

Target:

Glutathione S-transferase

Research Areas:

Inflammation/Immunology Cancer

TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a K_i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K_i of 0.56 μM.

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Keap1-Nrf2-IN-9

Cat. No.: HY-147517

CAS No.: 2769963-24-6

Purity: 98.52%

Target:

Keap1-Nrf2

Research Areas:

Neurological Disease Inflammation/Immunology

Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

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