275

740 Y-P

275 Publications Verification

Cat. No.: HY-P0175

CAS No.: 1236188-16-1

Synonyms: 740YPDGFR; PDGFR 740Y-P

Target:

PI3K Autophagy

Research Areas:

Cancer

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

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26

Anti-GST Magnetic Beads

26 Cited Publications

Cat. No.: HY-K0222

MCE Anti-GST Magnetic Beads are used for immunoprecipitation (IP) of specific GST-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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14

Glutathione Agarose

14 Cited Publications

Cat. No.: HY-K0211

MCE Glutathione Agarose, a 4% highly cross-linked agarose reagent, enables high-yield, high-purity purification of GST-tagged proteins.

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10

Ethacrynic acid

10 Cited Publications

Cat. No.: HY-B1640

CAS No.: 58-54-8

Synonyms: Etacrynic acid

Target:

Wnt Glutathione S-transferase NF-κB Calcium Channel NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .

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9

Thrombin (MW 37kDa)

9 Cited Publications

Cat. No.: HY-114164

CAS No.: 9002-04-4

Target:

Thrombin

Research Areas:

Neurological Disease

Thrombin (MW 37kDa) is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

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9

Thrombin, Pig blood

9 Cited Publications

Cat. No.: HY-114164C

CAS No.: 9002-04-4

Purity: 88.00%

Target:

Protease Activated Receptor (PAR) Thrombin

Research Areas:

Cardiovascular Disease

Rabbit Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

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9

Rat Thrombin

9 Cited Publications

Cat. No.: HY-114164D

CAS No.: 9002-04-4

Target:

Thrombin

Research Areas:

Cardiovascular Disease

Rat Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

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4

CHAPS

4 Cited Publications

Cat. No.: HY-15435

CAS No.: 75621-03-3

Purity: 99.91%

Target:

Exosomes Biochemical Assay Reagents

Research Areas:

Others

CHAPS is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm-Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS is commonly used in research on the separation and purification of membrane proteins .

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4

CHAPS hydrate

4 Cited Publications

Cat. No.: HY-15435A

CAS No.: 331717-45-4

Purity: ≥98.0%

CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins .

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3

NBDHEX

3 Cited Publications

Cat. No.: HY-135318

CAS No.: 787634-60-0

Purity: 98.56%

Target:

Apoptosis Autophagy Glutathione S-transferase

Research Areas:

Cancer

NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .

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