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54 Results for "

GTP activation

" in MedChemExpress (MCE) Product Catalog:

Products (54)

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Grassofermata

12 Publications Verification

Cat. No.: HY-112473

CAS No.: 419547-11-8

Purity: 99.10%

Synonyms: NAV-2729

Target:

Ras

Research Areas:

Cancer

Grassofermata is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily.

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ML-098

11 Cited Publications

Cat. No.: HY-19800

CAS No.: 878978-76-8

Synonyms: CID-7345532

Target:

Ras

Research Areas:

Cancer

ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC₅₀ of 77.6 nM.

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Pelitrexol

3 Cited Publications

Cat. No.: HY-14530

CAS No.: 446022-33-9

Purity: 98.94%

Synonyms: AG 2037

Target:

Antifolate

Research Areas:

Cancer

Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice .

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Nexinhib20

2 Cited Publications

Cat. No.: HY-125792

CAS No.: 331949-35-0

Purity: 99.69%

Target:

Reactive Oxygen Species (ROS) Ras Integrin

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Nexinhib20 is an inhibitor that targets the interactions of Rab27a-JFC1 (IC₅₀: 2.6 μM) and Rac-1-GTP. Nexinhib20 can inhibit neutrophil exocytosis, adhesion, and β2 integrin activation, and has anti-inflammatory activity. Nexinhib20 can be used in the research of diseases such as systemic inflammation and myocardial ischemia-reperfusion injury .

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