78 Results for "

Gene mutation

" in MedChemExpress (MCE) Product Catalog:
Products (78)

78 Results for "Gene mutation" in MCE Product Catalog:

36
Lavofloxacin lactate
Lavofloxacin lactate
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36 Publications Verification
Cat. No.: HY-B0013
CAS No.: 294662-18-3
Synonyms: (-)-Ofloxacin lactate
Target:  

Bacterial DNA/RNA Synthesis

Research Areas:  

Infection

Lavofloxacin lactate ((-)-ofloxacin lactate) is a class of broad-spectrum antimicrobials that can kill or inhibit a variety of bacteria. Lavofloxacin lactate binds to DNA rotase and topoisomerase IV, resulting in blocked DNA replication and repair, thus inhibiting bacterial growth. Lavofloxacin lactate can be used to study resistance mechanisms in bacteria, including studying resistance genes and mutations .
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Latozinemab
Latozinemab
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1 Cited Publications
Cat. No.: HY-P99688
CAS No.: 2376132-27-1
Synonyms: AL001

Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease Cancer

Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research .
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Ethyl methanesulfonate
Ethyl methanesulfonate
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Cat. No.: HY-W015854
CAS No.: 62-50-0
Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc .
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Enzomenib
Enzomenib
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Cat. No.: HY-156794
CAS No.: 2412555-70-3
Purity:  99.88%
Synonyms: DSP-5336
Target:  

Epigenetic Reader Domain FLT3

Research Areas:  

Cancer

Enzomenib (DSP-5336) is an orally active Menin inhibitor (IC50=1.4 nM, Kd=6.0 nM). Enzomenib disrupts the interaction between Menin and KMT2A/MLL fusion proteins, specifically inhibits the expression of leukemia driver genes such as HOX/MEIS1, and upregulates ITGAM. Enzomenib effectively induces cell differentiation, inhibits tumor cell proliferation, and suppresses primitive cell colony formation. Enzomenib reduces disease burden and prolongs survival, but causes adverse reactions including differentiation syndrome and QTc interval prolongation. Enzomenib is used for research on relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, and other hematologic malignancies with mixed lineage leukemia (MLL) rearrangements or NPM1 mutations .
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Oncrasin-1
Oncrasin-1
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Cat. No.: HY-16662
CAS No.: 75629-57-1
Target:  

DNA/RNA Synthesis Ras Apoptosis

Research Areas:  

Cancer

Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer .
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TASIN-1
TASIN-1
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Cat. No.: HY-116572A
CAS No.: 792927-06-1
Purity:  99.91%
Target:  

Reactive Oxygen Species (ROS) JNK Apoptosis Caspase

Research Areas:  

Cancer

TASIN-1 is a selective inhibitor of truncated APC TR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC mutant colorectal cancer .
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H3B-5942
H3B-5942
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Cat. No.: HY-112611
CAS No.: 2052128-15-9
Purity:  99.73%
Target:  

Estrogen Receptor/ERR

Research Areas:  

Cancer

H3B-5942 is a selective, irreversible and orally active estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERα by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. H3B-5942 reduces ERα target gene GREB1, shows potent antitumor activity both in multiple cell lines or animals bearing ERα WT or ERα mutations .
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Simtuzumab
Simtuzumab
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Cat. No.: HY-P99047
CAS No.: 1318075-13-6
Synonyms: AB 0024; GS 6624

Target:  

Monoamine Oxidase

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis .
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Tenecteplase
Tenecteplase
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Cat. No.: HY-108845
CAS No.: 191588-94-0
Synonyms: TNK-tPA
Target:  

Plasminogen/Plasmin Ser/Thr Protease

Research Areas:  

Cardiovascular Disease

Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke .
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Dihydralazine sulfate
Dihydralazine sulfate
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Cat. No.: HY-N7065
CAS No.: 7327-87-9
Target:  

Drug Derivative

Research Areas:  

Cardiovascular Disease Neurological Disease

Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .
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Ultevursen
Ultevursen
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Cat. No.: HY-147412
CAS No.: 2642382-41-8
Synonyms: QR-421a
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis

Research Areas:  

Neurological Disease

Ultevursen (QR-421a) is a splice-modulating antisense oligonucleotide targeting exon 13 of the USH2A gene, which restores the functional expression of Usherin protein by inducing exon skipping. Ultevursen binds to USH2A pre-mRNA and modulates the splicing process to specifically skip exon 13 carrying the pathogenic mutation c.2299delG, generating an in-frame transcript and a truncated yet functionally normal protein. Ultevursen exhibits concentration-dependent exon skipping activity in human cells and retinal organoid models, and restores Usherin expression and retinal function in zebrafish and gene-edited mouse models. Ultevursen can be used for related research on type 2 Usher syndrome and non-syndromic retinitis pigmentosa .
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Albizziin
Albizziin
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Cat. No.: HY-N12109
CAS No.: 585-23-9
Category:  

Microorganisms Ketones, Aldehydes, Acids 500 - Internal Server Error | MedChemExpress

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