232 Results for "

Glutamine

" in MedChemExpress (MCE) Product Catalog:
Products (232)

232 Results for "Glutamine" in MCE Product Catalog:

36
V-9302
V-9302
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36 Publications Verification
Cat. No.: HY-112683
CAS No.: 1855871-76-9
Purity:  99.88%
Target:  

ASCT

Research Areas:  

Cancer

V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 μM) in HEK-293 cells .
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36
V-9302 hydrochloride
V-9302 hydrochloride
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36 Publications Verification
Cat. No.: HY-112683A
CAS No.: 2416138-42-4
Purity:  99.10%
Target:  

ASCT

Research Areas:  

Cancer

V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells .
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33
L-Glutamine
L-Glutamine
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33 Cited Publications
Cat. No.: HY-N0390
CAS No.: 56-85-9
Synonyms: L-Glutamic acid 5-amide
Category:  

Anti-aging Metabolic Disease Endocrine diseases Amino acids Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Cancer

Target:  

Environmental Pollutants Endogenous Metabolite mGluR Ferroptosis

L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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19
6-Diazo-5-oxo-L-nor-Leucine
6-Diazo-5-oxo-L-nor-Leucine
0 Images
19 Cited Publications
Cat. No.: HY-108357
CAS No.: 157-03-9
Purity:  99.98%
Synonyms: L-6-Diazo-5-oxonorleucine; DON
Target:  

Glutaminase Bacterial Influenza Virus Antibiotic

Research Areas:  

Infection Cancer

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity .
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18
L-Asparaginase
L-Asparaginase
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18 Cited Publications
Cat. No.: HY-P1923
CAS No.: 9015-68-3
Synonyms: L-​ASNase
Target:  

Apoptosis DNA/RNA Synthesis

Research Areas:  

Cancer

L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .
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14
Succinyl phosphonate trisodium salt
Succinyl phosphonate trisodium salt
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14 Cited Publications
Cat. No.: HY-12688A
CAS No.: 864167-45-3
Purity:  ≥98.0%
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β

Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .
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13
L-Glutamine-13C5
L-Glutamine-13C5
0 Images
13 Cited Publications
Cat. No.: HY-N0390S1
CAS No.: 184161-19-1
Synonyms: L-Glutamic acid 5-amide-13C5
L-Glutamine- 13C5 is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
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7
L-Citrulline
L-Citrulline
0 Images
7 Cited Publications
Cat. No.: HY-N0391
CAS No.: 372-75-8
Category:  

Other Diseases Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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7
GPNA hydrochloride
GPNA hydrochloride
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7 Cited Publications
Cat. No.: HY-W011391
CAS No.: 67953-08-6
Target:  

Apoptosis ASCT

Research Areas:  

Cancer

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na +-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na +-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .
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7
L-Methionine-DL-sulfoximine
L-Methionine-DL-sulfoximine
0 Images
7 Cited Publications
Cat. No.: HY-B1692
CAS No.: 15985-39-4
Synonyms: MSX; MSO
Target:  

Glutaminase

Research Areas:  

Neurological Disease

L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS) .
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6
L-Theanine
L-Theanine
0 Images
6 Cited Publications
Cat. No.: HY-15121
CAS No.: 3081-61-6
Purity:  99.67%
Synonyms: L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-Glutamine
Category:  

Microorganisms Neurological Disease Anti-aging Amino acids Plants 500 - Internal Server Error | MedChemExpress

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