183

Docetaxel

183 Publications Verification

Cat. No.: HY-B0011

CAS No.: 114977-28-5

Synonyms: RP-56976

Category:

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .

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183

Docetaxel Trihydrate

183 Publications Verification

Cat. No.: HY-B0011A

CAS No.: 148408-66-6

Synonyms: RP-56976 Trihydrate

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .

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98

Verapamil

98 Cited Publications

Cat. No.: HY-14275

CAS No.: 52-53-9

Purity: 98.96%

Synonyms: (±)-Verapamil; CP-16533-1

Target:

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

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98

Verapamil hydrochloride

98 Cited Publications

Cat. No.: HY-A0064

CAS No.: 152-11-4

Synonyms: (±)-Verapamil hydrochloride; CP-16533-1 hydrochloride

Target:

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:

Cardiovascular Disease Cancer

Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

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61

Tariquidar methanesulfonate, hydrate

61 Cited Publications

Cat. No.: HY-10550A

CAS No.: 625375-83-9

Purity: 98.52%

Synonyms: XR9576 methanesulfonate, hydrate

Target:

P-glycoprotein

Research Areas:

Cancer

Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a K_d of 5.1 nM.

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61

Tariquidar

61 Cited Publications

Cat. No.: HY-10550

CAS No.: 206873-63-4

Purity: 99.45%

Synonyms: XR9576

Target:

P-glycoprotein

Research Areas:

Cancer

Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (K_d=5.1 nM) .

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32

Elacridar

32 Cited Publications

Cat. No.: HY-50879

CAS No.: 143664-11-3

Synonyms: GF120918; GW0918; GG918; GW120918

Target:

P-glycoprotein BCRP

Research Areas:

Cancer

Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer .

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32

Elacridar hydrochloride

32 Cited Publications

Cat. No.: HY-50880

CAS No.: 143851-98-3

Synonyms: GF120918A

Target:

P-glycoprotein BCRP

Research Areas:

Cancer

Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer .

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29

Glibenclamide

29 Cited Publications

Cat. No.: HY-15206

CAS No.: 10238-21-8

Purity: 99.94%

Synonyms: Glyburide

Target:

Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein

Research Areas:

Metabolic Disease

Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

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27

Trypsin

27 Cited Publications

Cat. No.: HY-129047

CAS No.: 9002-07-7

Purity: 91.00%

Target:

Ser/Thr Protease Protease Activated Receptor (PAR)

Research Areas:

Infection Inflammation/Immunology

Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation .

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24

Heparan Sulfate

24 Cited Publications

Cat. No.: HY-101916

CAS No.: 9050-30-0

Category:

Polysaccharides Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides

Target:

FGFR Wnt Endogenous Metabolite

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

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21

Deoxynivalenol

21 Cited Publications

Cat. No.: HY-N6684

CAS No.: 51481-10-8

Synonyms: Vomitoxin

Category:

Microorganisms Terpenoids Sesquiterpenes Metabolic Disease Disease Research Fields

Target:

P-glycoprotein

Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

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