9 Results for "

H226 cell

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "H226 cell" in MCE Product Catalog:

1
IL4RPep-1 acetate
IL4RPep-1 acetate
0 Images
1 Cited Publications
Cat. No.: HY-P11143A
Target:  

Interleukin Related Liposome

Research Areas:  

Cancer

IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1 acetate-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1 acetate-labeled liposomes accumulate more effectively within H226 tumors .
loading...
    loading...
View All Sizes
YAP/TEAD-IN-2
YAP/TEAD-IN-2
0 Images
Cat. No.: HY-175357
CAS No.: 2957895-40-6
Target:  

YAP

Research Areas:  

Cancer

YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor. YAP/TEAD-IN-2 inhibits the luciferase activity driven by YAP/TEAD in 293T cells. YAP/TEAD-IN-2 exhibits strong anti-proliferative activity against human pleural mesothelioma NCI-H226 cells. YAP/TEAD-IN-2 can be used for the study of diseases associated with Hippo pathway dysregulation, particularly cancers .
loading...
    loading...
View All Sizes
TEAD1/3/4-IN-1
TEAD1/3/4-IN-1
0 Images
Cat. No.: HY-174275
CAS No.: 2762619-63-4
Target:  

YAP

Research Areas:  

Inflammation/Immunology Cancer

TEAD1/3/4-IN-1 is an orally active inhibitor of TEAD1/3/4. TEAD1/3/4-IN-1 inhibits the YAP/TAZ-TEAD interaction, with its EC50 being 2 nM. TEAD1/3/4-IN-1 has anti-proliferative activity against NCI-H226 cells. TEAD1/3/4-IN-1 can be used in the research of lung squamous cell carcinoma .
loading...
    loading...
View All Sizes
M3686
M3686
0 Images
Cat. No.: HY-170764
CAS No.: 2738550-24-6
Target:  

YAP

Research Areas:  

Cancer

M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model .
loading...
    loading...
View All Sizes
pan-TEAD-IN-1
pan-TEAD-IN-1
0 Images
Cat. No.: HY-159912
CAS No.: 3027484-09-6
Target:  

YAP

Research Areas:  

Cancer

pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and Cyr61) in the Hippo signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC50 of 0.36 nM and an H226 cell IC50 of 1.52 nM. It also shows favorable pharmacokinetics (AUC0–∞ = 228.7 μg/mL·min, T1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers .
loading...
    loading...
View All Sizes
19-Hydroxy-10-deacetylbaccatin III
19-Hydroxy-10-deacetylbaccatin III
0 Images
Cat. No.: HY-N12004
CAS No.: 154083-99-5
Category:  

Taxaceae Extract Terpenoids Diterpenoids Plants 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.