HCV polymerase | MedChemExpress (MCE) Life Science Reagents

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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15

Dasabuvir

15 Cited Publications

Cat. No.: HY-13998

CAS No.: 1132935-63-7

Purity: 98.17%

Synonyms: ABT-333

Target:

Research Areas:

DNA/RNA Synthesis SARS-CoV RSV HCV Drug Metabolite

Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

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13

GS-443902 trisodium

13 Cited Publications

Cat. No.: HY-126303C

CAS No.: 1355050-21-3

Purity: 99.98%

Synonyms: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium

Target:

Research Areas:

CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV

GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC₅₀s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734) .

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12

NHC-triphosphate tetraammonium

12 Cited Publications

Cat. No.: HY-135867E

Purity: 97.09%

Target:

Research Areas:

NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

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8

PSI-7409 tetrasodium

8 Cited Publications

Cat. No.: HY-15745A

CAS No.: 1621884-22-7

Purity: 99.31%

Target:

Research Areas:

PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC₅₀s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.

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7

Mericitabine

7 Cited Publications

Cat. No.: HY-10240

CAS No.: 940908-79-2

Purity: 99.07%

Synonyms: RG 7128; R-7128; PSI 6130 diisobutyrate

Target:

Research Areas:

Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

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6

Nesbuvir

6 Cited Publications

Cat. No.: HY-14775

CAS No.: 691852-58-1

Purity: 99.21%

Synonyms: HCV-796

Target:

Research Areas:

Nesbuvir is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase.

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6

Beclabuvir

6 Cited Publications

Cat. No.: HY-12429

CAS No.: 958002-33-0

Purity: 99.94%

Synonyms: BMS-791325

Target:

DNA/RNA Synthesis HCV

Research Areas:

Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC₅₀ of < 28 nM .

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5

Tegobuvir

5 Cited Publications

Cat. No.: HY-10544

CAS No.: 1000787-75-6

Purity: 98.01%

Synonyms: GS 333126; GS-9190

Target:

Research Areas:

Tegobuvir is a specific, covalent inhibitor of the HCV NS5B polymerase.

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5

Balapiravir

5 Cited Publications

Cat. No.: HY-10443

CAS No.: 690270-29-2

Purity: 97.22%

Synonyms: Ro 4588161; R1626

Target:

Research Areas:

Balapiravir (Ro 4588161; R1626) is an orally active proagent of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir has anti-HCV activity . Balapiravir is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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4

TMC647055 Choline salt

4 Cited Publications

Cat. No.: HY-15591A

Purity: 99.82%

Target:

Research Areas:

TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC₅₀ value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV) .

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4

Filibuvir

4 Cited Publications

Cat. No.: HY-10118

CAS No.: 877130-28-4

Purity: ≥99.0%

Target:

Research Areas:

Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC₅₀s of 59 nM for both isoforms, respectively . Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation .

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3

PSI-6206

3 Cited Publications

Cat. No.: HY-15236

CAS No.: 863329-66-2

Purity: 99.89%

Synonyms: RO 2433; GS-331007

Target:

Research Areas:

PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC₉₀ of >100 μM.

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3

R-1479

3 Cited Publications

Cat. No.: HY-10444

CAS No.: 478182-28-4

Purity: 99.60%

Synonyms: 4'-Azidocytidine

Target:

Research Areas:

R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC₅₀=1.28 μM) . R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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3

VCH-916

3 Cited Publications

Cat. No.: HY-13465

CAS No.: 1200133-34-1

Purity: 98.38%

Target:

HCV Virus Protease

Research Areas:

VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection .

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2

PSI-6130

2 Cited Publications

Cat. No.: HY-10165

CAS No.: 817204-33-4

Purity: 99.39%

Synonyms: R 1656

Target:

Research Areas:

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC₅₀ of 0.6 μM.

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2

Lomibuvir

2 Cited Publications

Cat. No.: HY-75800

CAS No.: 1026785-55-6

Synonyms: VX-222

Target:

DNA/RNA Synthesis HCV

Research Areas:

Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a K_d of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC₅₀ of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis .

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1

NM107

1 Cited Publications

Cat. No.: HY-10468

CAS No.: 20724-73-6

Purity: 99.90%

Synonyms: 2'-C-Methylcytidine

Target:

Research Areas: