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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
HEMTACs
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "HEMTACs" in MCE Product Catalog:
Cat. No.: HY-173320
CAS No.: 3002417-64-0
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HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 (HSP90 enzyme inhibitory activity is IC50: 16.76 nM). HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1. HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker) .
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HEMTAC CDK4/6 degrader 1 is a HEMTAC connected by ligands for HSP90 and CDK4/6 with a Kd value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in research of cancer . HEMTAC CDK4/6 degrader 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-178472
CAS No.: 3106831-75-5
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AurAP14 is an Aurora A HSP90-mediated targeting chimera (HEMTAC) degrader (DC50 = 120 nM). AurAP14 can form a stable ternary complex with Aurora A kinase and HSP90, recruiting cullin family E3 ubiquitin ligases and MDM2 to mediate the ubiquitination and proteasome degradation of Aurora A kinase. AurAP14 increases p53 levels and decreases C-MYC levels; AurAP14 induces Apoptosis. AurAP14 can be used in the study of non-small cell lung cancer .
Cat. No.: HY-187229
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HSP70-mediated HEMTAC AR degrader-1 is an androgen receptor (AR) HEMTAC degrader that recruits HSP70, with a Kd value of 825 nM for HSP72. HSP70-mediated HEMTAC AR degrader-1 induces AR degradation, and inhibits the proliferation and migration of cancer cells. HSP70-mediated HEMTAC AR degrader-1 can be used in the research of prostate cancer .
Cat. No.: HY-187564
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HSP70 ligand 3 is a purine nucleoside intermediate that can serve as an HSP70 ligand for the synthesis of HSP70-based HEMTACs, such as HEMTAC AR degrader-1 (HY-187229) .
Cat. No.: HY-187565
CAS No.: 1189135-60-1
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Androgen receptor ligand 5 (Compound 7) is an Androgen receptor ligand. Androgen receptor ligand 5 can serve as a target protein ligand for the synthesis of HEMTAC AR degraders, such as HEMTAC AR degrader-1 (HY-187229). Androgen receptor ligand 5 can be used for research on prostate cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
