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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
HMOX1
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "HMOX1" in MCE Product Catalog:
18
3
2
2 Cited Publications
Cat. No.: HY-RS06249
Target:
Research Areas:
HMOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for HMOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
2
1
Cat. No.: HY-167874
CAS No.: 2488255-42-9
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ASP-8731 is an orally active BACH1 inhibitor. ASP-8731 activates antioxidant, anti-inflammatory and globin gene pathways by relieving the inhibitory effect of BACH1 on NRF2-mediated gene transcription. ASP-8731 significantly upregulates the expression of HMOX1, FTH1 and various globins (such as HGB, HBG, HBA), increases fetal hemoglobin (HbF) levels, and effectively induces F-cell production in hydroxyurea-unresponsive cells. Meanwhile, ASP-8731 reduces inflammatory responses and white blood cell counts by downregulating VCAM1, ICAM-1 and the phosphorylation level of NF-κB(p65), and blocks heme-induced glutathione depletion and microcirculatory stasis. ASP-8731 holds potential for inhibiting sickle cell disease and related hematological disorders [1].
Cat. No.: HY-124529
CAS No.: 37116-80-6
Category:
Conocephalum conicum (L.) Dumort. Extract Human Gut Microbiota Metabolites Plant Phenols Polyphenols Other Families Extract Endogenous metabolite
Target:
Cat. No.: HY-RS16718
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Research Areas:
Hmox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hmox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Research Areas:
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells [1].
Research Areas:
CCW16 is a non-selective cysteine-reactive covalent ligand and an RNF4 E3 ubiquitin ligase recruiter with an IC50 of 1.8 μM against human RNF4[. CCW16 covalently modifies accessible cysteine residues on RNF4, PRDX1, PRDX2, and PRDX6, attenuating the peroxide-scavenging activity of peroxiredoxins. CCW16 induces oxidative stress through upregulation of HMOX1 and NRF2, and triggers ferroptosis via lipid peroxidation and ROS signaling pathways in an RNF4-independent manner. CCW16 serves as an RNF4-recruiting moiety; it does not induce RNF4 degradation when used alone and can be used to synthesize protein degraders, such as the PROTAC compound CCW 28-3 (HY-156774). CCW16 can be used for research on acute myeloid leukemia and hepatocellular carcinoma [1] .
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CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress [1].
Cat. No.: HY-RS23153
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Research Areas:
Hmox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hmox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175806
CAS No.: 1372792-51-2
Research Areas:
CS47 is a Thioredoxin Reductase 1 (TRXR1) inhibitor and ferroptosis inducer. CS47 binds non-covalently to sites between the FAD and NADPH pockets of TRXR1. CS47 drives glutathione depletion, lipid reactive oxygen species accumulation, HMOX1-dependent iron overload, and selective cytotoxicity in lung cancer cells. CS47 can be used for the research of lung cancer [1].
Cat. No.: HY-173444
CAS No.: 2989934-63-4
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HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research [1].
Cat. No.: HY-124815R
CAS No.: 895470-67-4
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CP-312 (Standard) is the analytical standard of CP-312. This product is intended for research and analytical applications. CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress [1].
Cat. No.: HY-184288
Target:
Keap1-Nrf2 Heme Oxygenase (HO) Ferroptosis Glutathione Peroxidase MDM-2/p53 Reactive Oxygen Species (ROS)
Research Areas:
Nrf-2/HMOX-1-IN-1 is a Nrf-2 and HMOX-1 inhibitor, as well as a Ferroptosis inducer. Nrf-2/HMOX-1-IN-1 inhibits GPX activity and upregulates p53 gene expression. Nrf-2/HMOX-1-IN-1 increases intracellular ROS and MDA levels, reduces GSH content, and elevates intracellular iron levels simultaneously. Nrf-2/HMOX-1-IN-1 exerts selective anticancer effects against breast cancer. Nrf-2/HMOX-1-IN-1 can be used in breast cancer-related research [1].
Cat. No.: HY-P706203
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Heme oxygenase 1; EC:1.14.14.18; HO-1; HSP32; Heme oxygenase 1 soluble form 1 publication; HMOX1
Species:
Rat
Source:
P. pastoris
Cat. No.: HY-170968
CAS No.: 3037323-16-0
EGFR-IN-150 is an EGFR inhibitor that effectively suppresses the phosphorylation of mutant epidermal growth factor receptor (EGFR) and its downstream AKT signaling pathway, thereby exerting antitumor effects and inducing HMOX1 expression to trigger ferroptosis. EGFR-IN-150 exhibits an IC50 of 0.386 μM against the non-small cell lung cancer (NSCLC) cell line H1975, and significantly inhibits colony formation and migration of both H1975 and A549 cells while inducing apoptosis. In addition, EGFR-IN-150 markedly suppresses tumor growth in the H1975 cell-derived xenograft (CDX) mouse model. EGFR-IN-150 holds promise for research related to non-small cell lung cancer [1].
Cat. No.: HY-P700495
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMOX1; Heme Oxygenase; Heme Oxygenase 1; HMOX1D; HO-1; HSP32; BK286B10; HO1; Heme Oxygenase (Decycling) 1; HO; Heat Shock Protein, 32-KD
Species:
Mouse
Source:
P. pastoris
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
