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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
HOPS complex
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "HOPS complex" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N2787
CAS No.: 53846-50-7
Cat. No.: HY-184106
CAS No.: 1268273-85-3
HSP70-IN-9 is an Hsp70 inhibitor that induces caspase-3,7 activation with an IC50 of 25.2 μM. HSP70-IN-9 reversibly binds to the allosteric pocket of the N-terminal domain, disrupts the Hsp70-HOP-Hsp90 mega-complex, and inhibits client protein refolding, thereby inducing apoptosis and degradation of Hsp90-Hsp70 tumor client proteins, ultimately inhibiting cancer cell growth. HSP70-IN-9 can be used for research on breast cancer, pancreatic cancer, and acute myeloid leukemia .
Cat. No.: HY-184106A
HSP70-IN-9 dihydrochloride is an Hsp70 inhibitor that induces caspase-3,7 activation with an IC50 of 25.2 μM. HSP70-IN-9 dihydrochloride reversibly binds to the allosteric pocket of the N-terminal domain, disrupts the Hsp70-HOP-Hsp90 mega-complex, and inhibits client protein refolding, thereby inducing apoptosis and degradation of Hsp90-Hsp70 tumor client proteins, ultimately inhibiting cancer cell growth. HSP70-IN-9 dihydrochloride can be used for research on breast cancer, pancreatic cancer, and acute myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
