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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
HSC/HPCs
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "HSC/HPCs" in MCE Product Catalog:
116
116 Publications Verification
Synonyms: AMD 3100; JM3100; SID791
Research Areas:
Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
54
54 Cited Publications
Research Areas:
VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
13
13 Cited Publications
Synonyms: Apoptosis Activator VII
Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
3
3 Cited Publications
Cat. No.: HY-P73915A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HSPA8; Epididymis Secretory Sperm Binding Protein Li 72p; Prev. HSPA10; Constitutive Heat Shock Protein 70; HSC70; Epididymis Luminal Protein 33; HSP73; Heat Shock Cognate Protein 54; Heat Shock Cognate 71 KDa Protein; Heat Shock 70kd Protein 10; HSC71; H
Species:
Human
Source:
E. coli
2
2 Cited Publications
NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
2
INK4C-IN-2 is a p18 INK4C inhibitor. NK4C-IN-2 promotes hematopoietic stem cells (HSCs) division by inhibiting INK4C and activating CDK4/6, with an ED50 of 5.21 nM. INK4C-IN-2 shows no cytotoxic to normal 32D cells, HSCs, leukemia cell lines and myeloma cell lines .
1
1 Cited Publications
Cat. No.: HY-N3619
CAS No.: 142741-24-0
Target:
1
1 Cited Publications
Cat. No.: HY-P73915
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA8; Epididymis Secretory Sperm Binding Protein Li 72p; Prev. HSPA10; Constitutive Heat Shock Protein 70; HSC70; Epididymis Luminal Protein 33; HSP73; Heat Shock Cognate Protein 54; Heat Shock Cognate 71 KDa Protein; Heat Shock 70kd Protein 10; HSC71; Heat Shock 70kD Protein 8; Lipopolysaccharide-Associated Protein 1; HSPA8 Protein; Heat Shock Protein Family A Member 8; CDNA FLJ77848; Heat Shock 70 KDa Protein 8; HEL-S-72p; Heat Shock 70kDa Protein 8; HSC54; LPS-Associated Protein 1; HSP71; HEL-33; NIP71; LAP-1; LAP1; Heat Shock Protein Family A (Hsp70) Member 8; N-Myristoyltransferase Inhibitor Protein 71
Species:
Human
Source:
E. coli
Synonyms: 16,16-dimethyl PGE2
Target:
Research Areas:
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway .
Research Areas:
Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier .
Cat. No.: HY-P99488
CAS No.: 2574591-89-0
Synonyms: JSP-191; AMG-191
Target:
Research Areas:
MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer .
Cat. No.: HY-W107409
CAS No.: 213473-00-8
Category:
Target:
Target:
Research Areas:
BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins .
Target:
Research Areas:
MEISi-1 is a small-molecule inhibitor targeting the homeodomain of the MEIS1 protein. MEISi-1 significantly inhibits the activity of luciferase reporter genes containing MEIS binding sites (TGACAG), and induces the self-renewal of a key type of mouse and human hematopoietic stem cells (HSC) both in vitro and in vivo. MEISi-1 promotes cardiomyocyte proliferation and cytokinesis, reduces cardiac fibroblast proliferation, and upregulates the expression of cardiomyocyte-specific genes. MEISi-1 can be used in research on hematological diseases, cardiac regeneration and cancer .
Cat. No.: HY-D1613
CAS No.: 161106-88-3
Cat. No.: HY-100557D
CAS No.: 9004-64-2
Synonyms: Hydroxypropyl Cellulose, Viscosity(5%):75-150mPa.s, MW 100000
Cat. No.: HY-172275A
Target:
Research Areas:
DSPE-PEG2000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG2000-pPB can be used for drug delivery .
Cat. No.: HY-100557B
CAS No.: 9004-64-2
Synonyms: Hydroxypropyl Cellulose, Viscosity(1%):150-400mPa.s
Target:
Research Areas:
HPC, Viscosity (1%): 150-400 mPa.s (Hydroxypropyl Cellulose, Viscosity (1%): 150-400 mPa.s) is a non-ionic, biocompatible cellulose derivative. HPC, Viscosity (1%): 150-400 mPa.s serves as a thickener or gelling agent, lubricant, and emulsion stabilizer, and is also used in the preparation of capsules and films .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
