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34 Results for "

HSP-27

" in MedChemExpress (MCE) Product Catalog:

Products (34)

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657

Adezmapimod

657 Publications Verification

Cat. No.: HY-10256

CAS No.: 152121-47-6

Purity: 99.92%

Synonyms: SB 203580; RWJ 64809

Target:

Organoid p38 MAPK Autophagy Mitophagy HSP

Research Areas:

Inflammation/Immunology Cancer

Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator .

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ML346

8 Cited Publications

Cat. No.: HY-18669

CAS No.: 100872-83-1

Target:

HSP

Research Areas:

Cancer

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

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HSP27 inhibitor J2

7 Cited Publications

Cat. No.: HY-124653

CAS No.: 2133499-85-9

Purity: 99.70%

Synonyms: J2

Target:

HSP

Research Areas:

Cancer

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .

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Apatorsen sodium

2 Cited Publications

Cat. No.: HY-145722

CAS No.: 915443-09-3

Purity: 98.54%

Synonyms: OGX-427 sodium

Target:

HSP

Research Areas:

Cancer

Apatorsen (OGX-427) sodium is a 2'-methoxyethyl-modified antisense oligonucleotide and also a Hsp27 inhibitor. Apatorsen sodium reduces Hsp27 mRNA and protein levels, impairs stress-induced cytoprotective functions, induces cell apoptosis, inhibits tumor growth and prevents metastasis. Apatorsen sodium is applicable to research related to non-small cell lung cancer, castration-resistant prostate cancer, breast cancer, ovarian cancer and bladder cancer .

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Apatorsen

2 Cited Publications

Cat. No.: HY-145722A

CAS No.: 1002331-21-6

Synonyms: OGX-427

Target:

HSP

Research Areas:

Cancer

Apatorsen is a 2'-methoxyethyl-modified antisense oligonucleotide and also a Hsp27 inhibitor. Apatorsen reduces Hsp27 mRNA and protein levels, impairs stress-induced cytoprotective functions, induces cell apoptosis, inhibits tumor growth and prevents metastasis. Apatorsen is applicable to research related to non-small cell lung cancer, castration-resistant prostate cancer, breast cancer, ovarian cancer and bladder cancer .

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MK2-IN-5 acetate

1 Cited Publications

Cat. No.: HY-P10072A

Synonyms: HSP25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate

Target:

JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK

Research Areas:

Others

MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

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