30

Rosuvastatin Calcium

30 Publications Verification

Cat. No.: HY-17504

CAS No.: 147098-20-2

Synonyms: Rosuvastatin hemicalcium; ZD 4522 Calcium

Target:

HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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30

Rosuvastatin

30 Publications Verification

Cat. No.: HY-17504A

CAS No.: 287714-41-4

Synonyms: ZD 4522

Target:

HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks hERG current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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30

Rosuvastatin Sodium

30 Publications Verification

Cat. No.: HY-17504B

CAS No.: 147098-18-8

Synonyms: ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium

Target:

HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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8

ML346

8 Cited Publications

Cat. No.: HY-18669

CAS No.: 100872-83-1

Target:

HSP

Research Areas:

Cancer

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

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7

IR-780

7 Cited Publications

Cat. No.: HY-D1063

CAS No.: 207399-07-3

IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .

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2

Solanesol

2 Cited Publications

Cat. No.: HY-N0576

CAS No.: 13190-97-1

Category:

Other Terpenoids Neurological Disease Terpenoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP

Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder .

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2

YL-109

2 Cited Publications

Cat. No.: HY-18619

CAS No.: 36341-25-0

Target:

Aryl Hydrocarbon Receptor

Research Areas:

Cancer

YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .

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1

Rosuvastatin-d3 sodium

1 Cited Publications

Cat. No.: HY-17504BS

CAS No.: 1279031-70-7

Target:

Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy Bacterial

Rosuvastatin-d₃ sodium is the deuterated-labeled Rosuvastatin Sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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Zinc acetate

Cat. No.: HY-B1817

CAS No.: 557-34-6

Target:

Environmental Pollutants Apoptosis Biochemical Assay Reagents HSP

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Zinc acetate acts as an immune response modulator. Zinc acetate enhances the expression of HSP-70 mRNA. Zinc acetate restores the proliferation and cytokine production capacities of splenocytes. Zinc acetate reduces the Apoptosis level of splenocytes in endotoxemic mice. Zinc acetate increases plasma zinc levels and improves survival rates in mice with LPS-induced lethal endotoxemia. Zinc acetate induces rapid death of prostate cancer cell lines in vitro. Zinc acetate inhibits the growth of prostate cancer xenografts in SCID mice. Zinc acetate can be used in endotoxemia research .

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AEG3482

Cat. No.: HY-107599

CAS No.: 63735-71-7

Purity: 99.79%

Target:

JNK Apoptosis

Research Areas:

Neurological Disease

AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .

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Sodium lactate ringer's solution

Cat. No.: HY-158976

Synonyms: Lactated ringer's solution (LRS)

Target:

Biochemical Assay Reagents Collagen HSP

Research Areas:

Inflammation/Immunology

Sodium lactate ringer's solution (Lactated ringer's solution (LRS)) is an isotonic crystal intravenous injection and arthroscopic irrigation solution containing racemic sodium lactate and electrolytes such as sodium, potassium, calcium and chloride (130 mEq sodium/L, 274 mOsm/L), which can be used as a cell integrity protectant. Sodium lactate ringer's solution maintains the integrity of human meniscus cells, ensures that they retain normal cell morphology, membrane regularity, size and density, and does not alter the mRNA expression levels of α1 (I) procollagen, α1 (II) procollagen, aggrecan or HSP70. Sodium lactate ringer's solution can be applied to studies related to extracellular fluid deficiency and meniscus tears .

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EV206

Cat. No.: HY-168566

CAS No.: 2247047-81-8

Target:

HSP

Research Areas:

Cancer

EV206 is a Hsp70 binder and apoptosis inducer that binds to the N-terminal domain of Hsp70, promotes Hsp70 degradation via the ubiquitin-proteasome system, and reduces Hsp70 protein stability. EV206 induces apoptotic cell death, inhibits colony formation, and downregulates the expression of cancer stem cell-related markers in non-small cell lung cancer cells. EV206 inhibits the growth of H460 xenograft tumors in nude mice and can be used for the research of non-small cell lung cancer .

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