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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
HSPA5
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "HSPA5" in MCE Product Catalog:
34
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1 Cited Publications
Cat. No.: HY-P80496
Synonyms: GRP78, HSPA5, Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, Binding-immunoglobulin protein, Heat shock protein 70 family protein 5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein, GRP-78, BiP, HSP70 family protein 5
GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM) .
Cat. No.: HY-RS06432
Target:
Research Areas:
HSPA5 Human Pre-designed siRNA Set A contains three designed siRNAs for HSPA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06433
Target:
Research Areas:
Hspa5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hspa5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06434
Target:
Research Areas:
Hspa5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hspa5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-125974A
CAS No.: 1082532-95-3
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity .
Cat. No.: HY-100437R
CAS No.: 1609402-14-3
Target:
Research Areas:
HA15 (Standard) is the analytical standard of HA15 (HY-100437). This product is intended for research and analytical applications. HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity .
Cat. No.: HY-P790088
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-B
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71742
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-B
Species:
Mouse
Source:
P. pastoris
Cat. No.: HY-P704486
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-B
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P72239
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-B
Species:
Human
Source:
E. coli
Cat. No.: HY-P705465
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78; Heat Shock Protein 70 Family Protein 5; Epididymis Secretory Sperm Binding Protein Li 89n; Heat Shock Protein Family A Member 5; Endoplasmic Reticulum Chaperone BIP; Endoplasmic Reticulum Chaperone BiP; HEL-S-89n; 78 KDa Glucose-Regulated Protein; GRP-78; Binding-Immunoglobulin Protein; Heat Shock Protein Family A (Hsp70) Member 5; Glucose-Regulated Protein, 78kDa
Species:
Human
Source:
E. coli
Cat. No.: HY-187629
CAS No.: 2202678-04-2
Research Areas:
HH2853 is an orally active EZH1/EZH2 inhibitor, with an IC50 of 9.26 nM for EZH1 and IC50 values ranging from 2.21 to 3.75 nM for both wild-type and mutant EZH2 . HH2853 simultaneously inhibits the methyltransferase activities of EZH1 and EZH2, blocks the compensatory pathway that arises following EZH2 inhibition, and reduces H3K27me3 levels. HH2853 upregulates the expression of c-Myc and TfR-1 to induce intracellular iron accumulation, and stabilizes GPX4 via HSPA5 to suppress ferroptosis. HH2853 combined with Erastin (HY-15763) synergistically inhibits EZH2 wild-type DLBCL cell proliferation. HH2853 alone shows weak activity against EZH2 wild-type DLBCL and is well tolerated. HH2853 is applicable for research related to diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, epithelioid sarcoma, and follicular lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
