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41 Results for "

HT-1080

" in MedChemExpress (MCE) Product Catalog:

Products (41)

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1851

Ferrostatin-1

1851 Publications Verification

Cat. No.: HY-100579

CAS No.: 347174-05-4

Purity: 99.71%

Synonyms: Fer-1

Target:

Ferroptosis Fungal

Research Areas:

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .

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Ridaforolimus

14 Cited Publications

Cat. No.: HY-50908

CAS No.: 572924-54-0

Synonyms: MK-8669; Deforolimus; AP23573

Target:

mTOR Autophagy Bacterial

Research Areas:

Cancer

Ridaforolimus (MK-8669) is a potent and selective mTOR inhibitor; inhibits ribosomal protein S6 phosphorylation with an IC₅₀ of 0.2 nM in HT-1080 cells .

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DIF-3

8 Cited Publications

Cat. No.: HY-145669

CAS No.: 113411-17-9

Purity: 99.84%

Target:

Wnt CDK GSK-3

Research Areas:

Infection Cancer

DIF-3 is an orally active anticancer agent. DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in cells. DIF-3 induces reactive oxygen species (ROS) and autophagy. DIF suppresses the growth of Trypanosoma. cruzi in HT1080 cells. DIF-3 exerts antitumor effects both in vitro and in vivo .

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CC-3060

Cat. No.: HY-153698

CAS No.: 444288-86-2

Purity: 99.7%

Target:

Molecular Glues Ligands for E3 Ligase

Research Areas:

Cancer

CC-3060 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase and ZBTB16 degrader with a DC₅₀ of 0.47 nM in HT-1080 cells. CC-3060 engages structural degrons on ZBTB16’s ZnF1 or ZnF3 domains for fusion protein substrates. CC-3060 can be used for the research of acute promyelocytic leukemia .

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Methotrexate α-tert-butyl ester

Cat. No.: HY-133887

CAS No.: 79640-70-3

Purity: ≥96.0%

Target:

Antifolate DNA/RNA Synthesis

Research Areas:

Cancer

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .

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